strychnine   Click here for help

GtoPdb Ligand ID: 347

Synonyms: sanaseed | strychnin
PDB Ligand
Compound class: Natural product
Comment: Strychnine is a neurotoxin.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 32.78
Molecular weight 334.17
XLogP 0.56
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C1CC2OCC=C3C4C2C2N1c1ccccc1C12CCN(C1C4)C3
Isomeric SMILES O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3
InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
InChI Key QMGVPVSNSZLJIA-FVWCLLPLSA-N
Bioactivity Comments
Strychnine is an antagonist of glycine receptors and an allosteric modulator of muscarinic acetylcholine receptors.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M1 receptor Hs Allosteric modulator Neutral 4.9 – 5.0 pKd - 2-3
⤷ pKd 4.9 – 5.0 [2-3]
M2 receptor Hs Allosteric modulator Positive 4.9 – 5.0 pKd - 2-3,5
⤷ pKd 4.9 – 5.0 [2-3,5]
M3 receptor Hs Allosteric modulator Negative 4.2 – 5.7 pKd - 2-3
⤷ pKd 4.2 – 5.7 [2-3]
M1 receptor Hs Allosteric modulator Negative 4.9 pKd - 3
⤷ pKd 4.9 [3]
M4 receptor Hs Allosteric modulator Positive 4.8 – 5.0 pKd - 2-3
⤷ pKd 4.8 – 5.0 [2-3]
M5 receptor Hs Allosteric modulator Negative 3.6 pKd - 3
⤷ pKd 3.6 [3]
TAS2R46 Hs Agonist Agonist 6.4 pEC50 - 1
⤷ pEC50 6.4 (EC50 4.3x10-7 M) [1]
TAS2R10 Hs Agonist Agonist 4.5 pEC50 - 4
⤷ pEC50 4.5 (EC50 3.34x10-5 M) [4]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
glycine receptor α1 subunit Hs Antagonist Antagonist - - -
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glycine receptor α2 subunit Hs Antagonist Antagonist - - -
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glycine receptor α3 subunit Hs Antagonist Antagonist - - -
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nicotinic acetylcholine receptor α9 subunit Hs Antagonist Antagonist - - -
⤷ (α9)5
α9α10
nicotinic acetylcholine receptor α10 subunit Hs Antagonist Antagonist - - -
⤷ α9α10
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Commonly used antagonists at nicotinic acetylcholine receptor α8 subunit (avian) (α8)5: α-bungarotoxin > atropine ≥ tubocurarine ≥ strychnine
Commonly used antagonists at nicotinic acetylcholine receptor α9 subunit (α9)5: α-bungarotoxin > methyllycaconitine > strychnine ~ tropisetron > tubocurarine; α9α10: α-bungarotoxin > tropisetron = strychnine > tubocurarine
Commonly used antagonists at nicotinic acetylcholine receptor α10 subunit α9α10: α-bungarotoxin > tropisetron = strychnine > tubocurarine
Ligand mentioned in the following text fields
Glycine receptors overview
Acetylcholine receptors (muscarinic) comments
Glycine receptors comments