pravastatin   Click here for help

GtoPdb Ligand ID: 2953

Synonyms: Lipostat® | Pravachol® | pravastatin sodium
Approved drug
pravastatin is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Pravastatin is a statin anti-dyslipidemia drug. Chemically the compound is a derivative of mevastatin (compactin), which was originally isolated from Penicillium citrinum.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pravastatin

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 11
Topological polar surface area 124.29
Molecular weight 424.25
XLogP 2.27
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CCC(C(=O)OC1CC(O)C=C2C1C(CCC(CC(CC(=O)O)O)O)C(C=C2)C)C
Isomeric SMILES CC[C@@H](C(=O)O[C@H]1C[C@H](O)C=C2[C@H]1[C@@H](CC[C@H](C[C@H](CC(=O)O)O)O)[C@H](C=C2)C)C
InChI InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1
InChI Key TUZYXOIXSAXUGO-PZAWKZKUSA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
hydroxymethylglutaryl-CoA reductase Primary target of this compound Hs Inhibitor Competitive 7.0 pKi - 1
⤷ pKi 7.0 (Ki 1.03x10-7 M) [1]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: pH 6.8, concentrations of substrates: 100µM HMG-CoA, 270µM NADPH. Human HMG-COA reductase catalytic domain was expressed in Escherichia coli BL(DE3) cells and purified using a GST affinity column.
hydroxymethylglutaryl-CoA reductase Rn Inhibitor Competitive 8.4 pEC50 - 6
⤷ pEC50 8.4 (IC50 4.2x10-9 M) [6]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: In vitro HMG-CoA reductase inhibitory activity to inhibit sterol synthesis in cell free system in rat
hydroxymethylglutaryl-CoA reductase Rn Inhibitor Competitive 7.9 – 8.3 pIC50 - 2-4
⤷ pIC50 8.3 (IC50 5x10-9 M) [4]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: Sodium salt of pravastatin was tested for the inhibition of rat liver microsomal HMG-CoA reductase.
pIC50 8.2 (IC50 6.93x10-9 M) [2]
Description: in vitro inhibition of cholesterol synthesis
Conditions: Inhibition IC50 values measured in primary rat hepatocytes
pIC50 7.9 (IC50 1.3x10-8 M) [3]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: Concentration of substrate: 0.024µCi HMG-CoA, 15mM NADPH. Inhibition of HMG-CoA redcutase in Sprague-Dawley rat liver microsomes
hydroxymethylglutaryl-CoA reductase Primary target of this compound Hs Inhibitor Competitive 5.9 – 7.5 pIC50 - 5-6
⤷ pIC50 7.5 (IC50 3x10-8 M) [5]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: Concentrations of substrates: 0.45 µM HMG-CoA, 4mM NADPH. Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.
pIC50 5.9 (IC50 1.37x10-6 M) [6]
Description: In vitro inhibition of HMG-CoA reductase
Conditions: cellular assay testing the inhibition of steroidogenesis in Hep G2 cells (human hepatoma cell line)
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
OATP1B1 Hs None Binding - - -
⤷
Targets where the ligand is described in the comment field
Target Comment
OATP1B1 Other inhibitors include, fibrates, flavonoids, glitazones and macrolide antibacterials. Estrone-3-sulphate or the drug substrates atorvastatin, pravastatin and rosuvastatin are used as a probe.