cortisol   Click here for help

GtoPdb Ligand ID: 2868

Synonyms: Acticort® | Efmody® | Plenadren®
Approved drug PDB Ligand Immunopharmacology Ligand
cortisol is an approved drug (FDA (1953, prior history unavailable), EMA (2011))
Comment: Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 362.21
XLogP 0.55
No. Lipinski's rules broken 0
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Isomeric SMILES OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
InChI InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Natural/Endogenous Targets
Glucocorticoid receptor
Mineralocorticoid receptor
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Mineralocorticoid receptor Ligand is endogenous in the given species Hs Agonist Agonist 9.8 – 9.9 pIC50 - 1,3
pIC50 9.8 – 9.9 [1,3]
Glucocorticoid receptor Primary target of this compound Ligand is endogenous in the given species Hs Agonist Agonist 7.3 – 8.0 pIC50 - 1-3
pIC50 7.3 – 8.0 [1-3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields