Bc-III   

GtoPdb Ligand ID: 2615

Synonyms: major neurotoxin BcIII
Comment: Sea anemone toxin III from Bunodosoma caissarum.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.1 Hs Gating inhibitor Slows inactivation 6.5 pEC50 - 1
pEC50 6.5 Inhibitor of fast activation [1]
Voltage: -80.0 mV
Nav1.5 Hs Gating inhibitor Slows inactivation 6.5 pEC50 - 1
pEC50 6.5 Inhibitor of fast activation [1]
Voltage: -80.0 mV
Nav1.4 Hs Gating inhibitor Slows inactivation 6.1 pEC50 - 1
pEC50 6.1 [1]
Voltage: -80.0 mV
Nav1.6 Hs Gating inhibitor Slows inactivation 6.0 pEC50 - 1
pEC50 6.0 [1]
Voltage: -80.0 mV
Nav1.2 Hs Gating inhibitor Slows inactivation 5.8 pEC50 - 1
pEC50 5.8 Inhibitor of fast activation [1]
Voltage: -80.0 mV
Nav1.3 Hs Gating inhibitor Slows inactivation 5.8 pEC50 - 1
pEC50 5.8 [1]
Voltage: -80.0 mV