Synonyms: ang II | Giapreza®
angiotensin II is an approved drug (FDA (2017))
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Endogenous angiotensin II is a vasopressor.
Species: Human, Mouse, Rat
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: angiotensin ii |
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Natural/Endogenous Targets | |||
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||
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Selectivity at GPCRs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Endogenous substrates at Angiotensin-converting enzyme | angiotensin I (AGT, P01019) > angiotensin II (AGT, P01019) |
Targets where the ligand is described in the comment field | |
Target | Comment |
Aminopeptidase A | Hydrolyses CCK-8 (CCK, P06307) [5], angiotensin II (AGT, P01019) [9], neurokinin B (TAC3, Q9UHF0), chromogranin A (CHGA, P10645), kallidin (KNG1, P01042) [3] |
Ligand mentioned in the following text fields |
Angiotensin receptors overview |