Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference DMT1 Zinc transporter 8 4,12 Zinc transporter 14 5 Solute carrier family 41 member 1 6

Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference Cav1.3 N/A Channel blocker Antagonist - - 2x10-4 16 ⤷ Conc range: 2x10-4 M [16] Voltage: -60.0 mV TRPP1 Hs Channel blocker - - - 1x10-4 15 ⤷ Conc range: 1x10-4 M [15] Voltage: 0.0 mV TRPA1 Hs Activator Activation 5.8 pEC50 - 1,13 ⤷ pEC50 5.8 (EC50 1.4x10-6 M) [1,13] Description: Sodium and calcium imaging Conditions: CHO cells expressing human TRPA1 and mouse dorsal root ganglion neurons TRPA1 Mm Activator Activation 5.7 pEC50 - 1,13 ⤷ pEC50 5.7 (EC50 2.1x10-6 M) [1,13] Cav2.1 Oc Channel blocker - 6.0 – 6.3 pIC50 - ⤷ pIC50 6.0 – 6.3 Voltage: -80.0 – -60.0 mV Cav2.3 Hs Channel blocker Antagonist 6.1 pIC50 - 18 ⤷ pIC50 6.1 [18] Voltage: -90.0 mV Cav1.2 Oc Channel blocker - 5.7 – 6.0 pIC50 - 7 ⤷ pIC50 5.7 – 6.0 [7] Voltage: -80.0 mV Hv1 Hs Channel blocker - ~5.0 pIC50 - ⤷ pIC50 ~5.0 (IC50 ~1x10-5 M) Cav1.1 Rn Channel blocker Antagonist 4.3 pIC50 - 2 ⤷ pIC50 4.3 [2] Voltage: -80.0 mV ClC-4 Hs Channel blocker - 4.2 pIC50 - 14 ⤷ pIC50 4.2 (IC50 6.8x10-5 M) [14] Navi2.1 Hs Channel blocker - 3.8 pIC50 - ⤷ pIC50 3.8 (IC50 1.5x10-4 M) TPC1 Hs Channel blocker Inhibition 3.7 pIC50 - 3 ⤷ pIC50 3.7 (IC50 1.8x10-4 M) [3] CatSper1 Mm Channel blocker Inhibition 3.7 pIC50 - 10 ⤷ pIC50 3.7 (IC50 2x10-4 M) [10] Description: Whole cell patch clamp CatSper2 Mm Channel blocker Inhibition 3.7 pIC50 - 9 ⤷ pIC50 3.7 (IC50 2x10-4 M) [9] Description: Whole cell patch clamp. CatSper3 Mm Channel blocker Antagonist 3.7 pIC50 - 10 ⤷ pIC50 3.7 (IC50 2x10-4 M) [10] Description: Whole cell patch clamp electrophysiology. CatSper4 Mm Channel blocker Antagonist 3.7 pIC50 - 10 ⤷ pIC50 3.7 (IC50 2x10-4 M) [10] Description: Whole cell patch clamp electrophysiology. TRPC6 Mm Channel blocker Antagonist 3.6 pIC50 - 8 ⤷ pIC50 3.6 (IC50 2.53x10-4 M) [8] Voltage: -60.0 mV Nav1.7 Hs Channel blocker Pore blocker 3.0 pIC50 - 11 ⤷ pIC50 3.0 [11] Voltage: -100.0 mV ASIC2 Hs Channel blocker - ~3.0 pIC50 - 17 ⤷ pIC50 ~3.0 (IC50 ~1x10-3 M) Partial inhibition [17] TRPV6 Hs Channel blocker - - - - ⤷ Kv12.1 Mm Gating inhibitor - - - - 19 ⤷ [19] Description: 1 mM Cd2+ slows activation 5-fold and shifts V0.5 for activation by +35 mV Conditions: Heterologous expression in Xenopus oocytes ClC-1 Hs Channel blocker - - - - ⤷ ClC-2 Hs Channel blocker - - - - ⤷

Additional information and targets (data relate to human unless otherwise stated)
Description	Data	Reference
Other channel blockers at TRPV5	Pb2+ = Cu2+ = Gd3+ > Cd2+ > Zn2+ > La3+ > Co2+ > Fe2