ruthenium red   Click here for help

GtoPdb Ligand ID: 2432

Synonyms: ammoniated ruthenium oxychloride
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM6 Hs Channel blocker Antagonist - - 1x10-7 - 1x10-5 10
⤷ Conc range: 1x10-7 - 1x10-5 M [10]
Voltage: -120.0 – -20.0 mV
TRPV4 Mm Channel blocker Antagonist - - 1x10-6 11
⤷ Conc range: 1x10-6 M [11]
Voltage: 0.0 mV
TRPM6 Hs Channel blocker - 7.0 pIC50 -
⤷ pIC50 7.0 (IC50 1x10-7 M)
Voltage: -120.0 mV
TRPV1 Hs Channel blocker Antagonist 7.0 pIC50 - 6
⤷ pIC50 7.0 [6]
Voltage: -60.0 mV
TRPV5 Oc Channel blocker Inhibition 6.9 pIC50 - 8
⤷ pIC50 6.9 (IC50 1.11x10-7 M) [8]
Voltage: -150.0 – 100.0 mV
TRPV5 Hs Channel blocker - 6.9 pIC50 -
⤷ pIC50 6.9 (IC50 1.21x10-7 M)
TRPV1 Hs Channel blocker - 6.7 – 7.0 pIC50 -
⤷ pIC50 6.7 – 7.0 (IC50 2.2x10-7 – 9x10-8 M)
TRPV1 Rn Channel blocker Antagonist 6.7 pIC50 - 6
⤷ pIC50 6.7 [6]
Voltage: -60.0 mV
TRPV4 Rn Channel blocker Inhibition 6.7 pIC50 - 2
⤷ pIC50 6.7 [2]
TRPV2 Hs Channel blocker - 6.2 pIC50 -
⤷ pIC50 6.2 (IC50 6x10-7 M)
TRPV2 Mm Channel blocker Antagonist 6.2 pIC50 - 1
⤷ pIC50 6.2 [1]
Voltage: -40.0 mV
K2P9.1 N/A Channel blocker - 6.2 pIC50 -
⤷ pIC50 6.2
TRPV3 Mm Channel blocker Inhibition 6.0 pIC50 - 9
⤷ pIC50 6.0 [9]
Description: Patch clamp electrophysiology
TRPA1 Mm Channel blocker Inhibition 5.5 pIC50 - 7
⤷ pIC50 5.5 (IC50 3.55x10-6 M) [7]
Voltage: -80.0 mV
CatSper1 Mm Channel blocker Inhibition 5.0 pIC50 - 5
⤷ pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp
CatSper2 Mm Channel blocker Antagonist 5.0 pIC50 - 4
⤷ pIC50 5.0 (IC50 1x10-5 M) [4]
Description: Whole cell patch clamp.
CatSper3 Mm Channel blocker Antagonist 5.0 pIC50 - 5
⤷ pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp electrophysiology.
CatSper4 Mm Channel blocker Antagonist 5.0 pIC50 - 5
⤷ pIC50 5.0 (IC50 1x10-5 M) [5]
Description: Whole cell patch clamp electrophysiology.
TRPV6 Mm Channel blocker Antagonist 5.0 pIC50 - 3
⤷ pIC50 5.0 (IC50 9x10-6 M) [3]
Voltage: -80.0 mV
K2P9.1 Hs Inhibitor - - - -
⤷
RyR1 Hs Channel blocker - - - -
⤷
RyR2 Hs Channel blocker - - - -
⤷
RyR3 Hs Channel blocker - - - -
⤷
Targets where the ligand is described in the comment field
Target Comment
TRPM8 Cannabidiol and Δ9-tetrahydrocannabinol are examples of cannabinoid activators. TRPM8 is insensitive to ruthenium red. Icilin requires intracellular Ca2+ for full agonist activity.