Ba2+   Click here for help

GtoPdb Ligand ID: 2344

Synonyms: barium ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Solute carrier family 41 member 1 6
Solute carrier family 41 member 2 7
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir5.1 Rn Channel blocker Antagonist - - 3x10-3 28
⤷ Conc range: 3x10-3 M Kir5.1 expressed with PSD-95 [28]
Voltage: -120.0 – 20.0 mV
K2P18.1 N/A Channel blocker - - - 2.5x10-3 - 3x10-3
⤷ Conc range: 2.5x10-3 - 3x10-3 M
K2P4.1 Rn Channel blocker - - - 2x10-3 10
⤷ Conc range: 2x10-3 M [10]
Kir1.1 Hs Channel blocker Antagonist - - 1x10-3 24
⤷ Conc range: 1x10-3 M [24]
Voltage: -160.0 – 80.0 mV
K2P16.1 Hs Channel blocker - - - 1x10-3 5
⤷ Conc range: 1x10-3 M [5]
Kir4.1 Rn Channel blocker Antagonist - - 3x10-6 - 1x10-3 11,27,29
⤷ Conc range: 3x10-6 - 1x10-3 M [11,27,29]
Voltage: -160.0 – 60.0 mV
Kir3.1 Hs Channel blocker Antagonist - - 1x10-4 - 3x10-4 23
⤷ Conc range: 1x10-4 - 3x10-4 M [23]
Voltage: Physiological
Kir3.1 Rn Channel blocker Antagonist - - 1x10-4 - 2.5x10-4 3
⤷ Conc range: 1x10-4 - 2.5x10-4 M [3]
Voltage: Physiological
Kir4.2 Mm Channel blocker Antagonist - - 1x10-5 - 1x10-4 21
⤷ Conc range: 1x10-5 - 1x10-4 M Kir4.2 expressed in Xenopus oocytes [21]
Voltage: -120.0 – 100.0 mV
Kir2.2 Mm Gating inhibitor Antagonist - - 5x10-5 26
⤷ Conc range: 5x10-5 M [26]
Voltage: -150.0 – -50.0 mV
Kir2.1 Mm Channel blocker Antagonist 3.9 – 5.6 pKd 1x10-6 - 1x10-4 1
⤷ pKd 3.9 – 5.6 Conc range: 1x10-6 - 1x10-4 M [1]
Voltage: 0.0 – -80.0 mV
Kir2.4 Hs Channel blocker Antagonist 3.3 pKd - 9
⤷ pKd 3.3 [9]
Voltage: 0.0 mV
Kv2.1 Rn Channel blocker (Extracellular Ba2+) - 1.5 – 4.9 pKd - 25
⤷ pKd 4.9 [25]
pKd 1.5 [25]
Kir2.2 Rn Gating inhibitor Antagonist 5.2 pKi - 32
⤷ pKi 5.2 [32]
Voltage: -80.0 mV
Kir2.4 Rn Channel blocker Antagonist 3.4 – 4.2 pKi 1x10-6 - 1x10-3 31-32
⤷ pKi 3.4 – 4.2 Conc range: 1x10-6 - 1x10-3 M [31-32]
Voltage: -80.0 – -100.0 mV
Kir7.1 Hs Channel blocker Antagonist 3.2 pKi - 4,13-14,19
⤷ pKi 3.2 [4,13-14,19]
Voltage: -100.0 mV
Kir3.4 Rn Channel blocker Antagonist 3.3 pEC50 - 12
⤷ pEC50 3.3 [12]
Voltage: -80.0 mV
Kir2.3 Mm Channel blocker Antagonist 5.2 pIC50 5x10-6 - 5x10-4 16,18
⤷ pIC50 5.2 Conc range: 5x10-6 - 5x10-4 M [16,18]
Voltage: -150.0 mV
Kir2.3 Hs Channel blocker Antagonist 5.0 pIC50 3x10-6 - 5x10-4 17,22,30
⤷ pIC50 5.0 Conc range: 3x10-6 - 5x10-4 M [17,22,30]
Voltage: -60.0 mV
Kir3.1 Rn Channel blocker Antagonist 4.7 pIC50 - 3
⤷ pIC50 4.7 Kir3.1 expressed in Xenopus oocytes [3]
Kv12.1 Hs Channel blocker - 3.7 pIC50 - 34
⤷ pIC50 3.7 [34]
Kir1.1 Rn Channel blocker Antagonist 2.3 – 4.2 pIC50 1x10-4 8,33
⤷ pIC50 2.3 – 4.2 Conc range: 1x10-4 M [8,33]
Voltage: 0.0 – -100.0 mV
KNa1.2 Hs Channel blocker Inhibition 3.0 pIC50 - 2
⤷ pIC50 3.0 [2]
Kv1.8 Hs Channel blocker - 2.3 pIC50 - 15
⤷ pIC50 2.3 [15]
K2P3.1 Hs Channel blocker - 0.3 pIC50 -
⤷ pIC50 0.3
K2P6.1 Rn Channel blocker - - pIC50 1x10-5 - 1x10-4 20
⤷ pIC50 Conc range: 1x10-5 - 1x10-4 M [20]
K2P13.1 N/A Channel blocker - - - -
⤷