desmopressin   Click here for help

GtoPdb Ligand ID: 2182

Synonyms: 1-deamino,D-AVP | [deamino-Cys1,D-Arg8]vasopressin | dDAVP | Noctiva®
Approved drug
desmopressin is an approved drug (FDA (1978))
Compound class: Peptide or derivative
Comment: Synthetic analogue of AVP. As is the case with many peptide molecules, there is ambiguity in the stereochemistry of the chemical structure of desmopressin. The structure shown here does not specify stereochemistry and so may vary from the representations shown on other resources linked to from the table above. PubChem also includes the following structures for desmopressin: (CID 16051933 and CID 5311065).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O
Isomeric SMILES NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O
InChI InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)
InChI Key NFLWUMRGJYTJIN-UHFFFAOYSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
V2 receptor Rn Agonist Full agonist 8.7 pKi - 3
⤷ pKi 8.7 [3]
V1B receptor Rn Agonist Partial agonist 8.0 pKi - 7
⤷ pKi 8.0 [7]
V1B receptor Hs Agonist Full agonist 7.7 – 8.2 pKi - 1,5,7,10
⤷ pKi 7.7 – 8.2 [1,5,7,10]
V2 receptor Hs Agonist Full agonist 7.2 – 8.6 pKi - 1-3,5,7-10
⤷ pKi 7.2 – 8.6 (Ki 6.3x10-8 – 2.5x10-9 M) [1-3,5,7-10]
V1A receptor Hs Agonist Full agonist 7.0 – 7.7 pKi - 1,5-7,9-10
⤷ pKi 7.0 – 7.7 [1,5-7,9-10]
OT receptor Hs Agonist Full agonist 6.7 – 7.6 pKi - 2,4
⤷ pKi 6.7 – 7.6 [2,4]
V1A receptor Rn Agonist Full agonist 5.6 pKi - 2
⤷ pKi 5.6 [2]
Ligand mentioned in the following text fields
Vasopressin and oxytocin receptors comments