SRIF-28   Click here for help

GtoPdb Ligand ID: 2020

Synonyms: somatostatin 1-28 | SST-28
Compound class: Endogenous peptide in human, mouse or rat
Comment: As with many peptide molecules there is some ambiguity in the literature as to the exact stereochemistry of SRIF-28. The structure shown here matches that shown in the PubChem entry linked to above, but the compound is also represented by CHEMBL442494 and CID 44388117.
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NCCCCC(C(=O)NC(C(=O)NCC(=O)NC1CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCCCN)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CCCCN)C(O)C)C(O)C)C(=O)O)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CO)N)C)CC(=O)N)CO)CC(=O)N)C)CCSC)C)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N
Isomeric SMILES NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCCN)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CCCCN)[C@H](O)C)[C@H](O)C)C(=O)O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)C)CC(=O)N)CO)CC(=O)N)C)CCSC)C)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N
InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/m0/s1
InChI Key GGYTXJNZMFRSLX-DFTNLTQTSA-N
Natural/Endogenous Targets
Target
SST1 receptor
SST2 receptor
SST3 receptor
SST4 receptor
SST5 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST5 receptor Ligand is endogenous in the given species Mm Agonist Full agonist 9.8 – 9.9 pKi - 4
⤷ pKi 9.8 – 9.9 [4]
SST5 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 9.2 – 10.3 pKi - 1,3,5-6,8-10
⤷ pKi 9.2 – 10.3 [1,3,5-6,8-10]
SST2 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.4 – 10.2 pKi - 1,3,6,8-10
⤷ pKi 8.4 – 10.2 [1,3,6,8-10]
SST3 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 9.1 pKi - 5
⤷ pKi 9.1 [5]
SST1 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.6 – 9.4 pKi - 1,3,5-6,8,10
⤷ pKi 8.6 – 9.4 [1,3,5-6,8,10]
SST3 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.1 – 9.9 pKi - 1-3,5-6,8,10
⤷ pKi 8.1 – 9.9 [1-3,5-6,8,10]
SST5 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 9.0 pKi - 5
⤷ pKi 9.0 [5]
SST2 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 8.8 pKi - 5
⤷ pKi 8.8 [5]
SST4 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.1 – 9.2 pKi - 1,3,5-6,8,10
⤷ pKi 8.1 – 9.2 [1,3,5-6,8,10]
MRGPRX2 Hs Agonist Agonist 5.4 pEC50 - 11
⤷ pEC50 5.4 (EC50 4.17x10-6 M) [11]
Description: In a calcium mobilisation assay.
SST3 receptor Ligand is endogenous in the given species Mm Agonist Full agonist 10.2 pIC50 - 7
⤷ pIC50 10.2 [7]
SST2 receptor Ligand is endogenous in the given species Mm Agonist Full agonist 9.0 – 9.5 pIC50 - 5
⤷ pIC50 9.0 – 9.5 [5]
Ligand mentioned in the following text fields
Somatostatin receptors overview