iloprost   Click here for help

GtoPdb Ligand ID: 1895

Synonyms: Aurlumyn® | Ventavis®
Approved drug Immunopharmacology Ligand
iloprost is an approved drug (EMA (2003), FDA (2004))
Compound class: Synthetic organic
Comment: Iloprost is a synthetic analogue of PGI2.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.76
Molecular weight 360.23
XLogP 3.19
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC#CCC(C(C=CC1C(O)CC2C1CC(=CCCCC(=O)O)C2)O)C
Isomeric SMILES CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C
InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18?,19-,20+,21+/m0/s1
InChI Key HIFJCPQKFCZDDL-SGSAMSKHSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IP receptor Mm Agonist Full agonist 8.0 pKi - 4
⤷ pKi 8.0 [4]
EP1 receptor Rn Agonist Partial agonist 7.9 pKi - 2
⤷ pKi 7.9 [2]
IP receptor Primary target of this compound Hs Agonist Full agonist 7.5 – 8.0 pKi - 1,7
⤷ pKi 7.5 – 8.0 [1,7]
EP1 receptor Mm Agonist Full agonist 7.7 pKi - 4
⤷ pKi 7.7 [4]
EP3 receptor Mm Agonist Full agonist 7.7 pKi - 4
⤷ pKi 7.7 (Ki 2.2x10-8 M) [4]
EP3 receptor Rn Agonist Full agonist 7.3 pKi - 2
⤷ pKi 7.3 (Ki 4.7x10-8 M) EP3α isoform [2]
EP3 receptor Hs Agonist Full agonist 6.7 – 7.3 pKi - 1,6
⤷ pKi 7.3 (Ki 5.6x10-8 M) EP3-III isoform [1]
pKi 6.7 (Ki 2.08x10-7 M) EP3-I isoform [6]
EP1 receptor Hs Agonist Full agonist 5.6 – 8.0 pKi - 1,5
⤷ pKi 5.6 – 8.0 [1,5]
DP1 receptor Hs Agonist Full agonist 6.0 – 6.6 pKi - 1,6,8
⤷ pKi 6.0 – 6.6 [1,6,8]
FP receptor Hs Agonist Full agonist 6.2 pKi - 1
⤷ pKi 6.2 [1]
EP2 receptor Rn Agonist Full agonist 5.9 pKi - 2
⤷ pKi 5.9 [2]
EP2 receptor Mm Agonist Full agonist 5.8 pKi - 4
⤷ pKi 5.8 [4]
EP2 receptor Hs Agonist Full agonist 5.7 pKi - 1
⤷ pKi 5.7 [1]
EP4 receptor Hs Agonist Full agonist 4.6 – 6.7 pKi - 1,3,6
⤷ pKi 4.6 – 6.7 (Ki 2.3x10-5 – 2.1x10-7 M) [1,3,6]
EP4 receptor Mm Agonist Full agonist 5.6 pKi - 4
⤷ pKi 5.6 [4]
TP receptor Hs Agonist Full agonist 5.2 pKi - 1
⤷ pKi 5.2 [1]
EP3 receptor Rn Agonist Full agonist 9.2 pEC50 - 2
⤷ pEC50 9.2 (EC50 6.3x10-10 M) EP3α isoform [2]
EP4 receptor Hs Agonist Full agonist 6.4 pEC50 - 6
⤷ pEC50 6.4 (EC50 4x10-7 M) [6]
Ligand mentioned in the following text fields
Prostanoid receptors comments