Abbreviated name: UDP
Synonyms: 5'-UDP | uridine 5'-diphosphate | uridine diphosphate
Compound class:
Metabolite
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Natural/Endogenous Targets | ||||
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||
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Selectivity at GPCRs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order of endogenous ligands at P2Y14 receptor | UDP= UDP-glucose | |
Potency order of endogenous ligands at P2Y6 receptor | UDP >> UTP > ADP |
Targets where the ligand is described in the comment field | |
Target | Comment |
GPR17 | Reported to be a dual leukotriene and UDP receptor [4]. Another group instead proposed that GPR17 functions as a negative regulator of the CysLT1 receptor response to leukotriene D4 (LTD4). For further discussion, see [6]. Reported to antagonize CysLT1 receptor signalling in vivo and in vitro [8]. See reviews [2] and [6]. |
Ligand mentioned in the following text fields |
P2Y receptors overview |