Synonyms: danfensuan B | SalB
Compound class:
Natural product
Comment: Salvianolic acid B is a plant-derived stilbenoid. A number of salvianolic acids have been extracted from a range of plants, some of which are used in Chinese herbal medicines (e.g. Danshen, Salvia miltiorrhiza). The therapeutic potential of salvianolic acids is under investigation [9], based on their proposed pharmacological effects which include anti-oxidant, anti-fibrotic, anti-coagulant/anti-thrombotic, anti-inflammatory and anti-tumour activities [2-3,13,16-17]. Specifically, salvianolic acid B is reported to directly interact with the platelet-derived growth factor receptor β (PDGFRβ) [6], which is a well established fibrosis target that is expressed by hepatic stellate cells [1,8,14-15]. Inhibition of lysine-specific demethylase 1 (LSD1; KDM1A, an anticancer target) has also been reported [4].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Experimental evidence suggests that SalB's anti-liver fibrosis action is mediated by regulation of the PDGF/PDGFRβ signalling pathway and inhibition of hepatic stellate cell activation (determined as inhibtion of α-SMA and collagen I expression) [7]. In addition, SalB inhibits aggregation and activation of platelets in in vitro and in vivo models [10-12]. |
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