Synonyms: compound 43 [PMID: 38556760] | UNC-8969
Compound class:
Synthetic organic
Comment: UNC8969 is reported as a macrocyclic dual MERTK and AXL receptor tyrosine kinases (RTK) inhibitor [1]. It was designed to induce tumour cell killing in malignancies such as non-small cell lung cancer (NSCLC).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Bioactivity Comments |
Exhibits ~10-fold selectivity for MERTK and AXL compared to the other TAM family (Type XI) RTK TYRO3 and the Type III RTK FLT3 in vitro [1]. |
Selectivity at catalytic receptors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|