epcoritamab   Click here for help

GtoPdb Ligand ID: 11442

Synonyms: epcoritamab-bysp | Epkinly® | GEN-3013 | GEN3013 | Tepkinly®
Approved drug Immunopharmacology Ligand
epcoritamab is an approved drug (FDA & EMA (2023))
Compound class: Antibody
Comment: Epcoritamab (GEN3013) is a novel CD3ε/CD20 bispecific IgG1 antibody that redirects CD3+ cytotoxic T cells to selectively destroy CD20+ve malignant B cells [1-2]. Its Fc domain has been mutated to prevent FcγR and complement binding.
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD20 (membrane-spanning 4-domains, subfamily A, member 1) Hs Antibody Binding - - - 1
⤷ [1]
CD3e Hs Antibody Binding - - - 1
⤷ [1]