dapirolizumab pegol   Click here for help

GtoPdb Ligand ID: 11123

Synonyms: CDP-7657 | CDP7657 | DZP
Immunopharmacology Ligand
Compound class: Antibody
Comment: Dapirolizumab pegol (CDP7657) is a pegylated monovalent Fab' immunomodulator that targets CD40 ligand [1]. It was developed by UCB Pharma. Removal of the Fc domain prevented the increased risk of thrombotic events observed with an intact mAb.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD40 ligand Hs Antibody Binding 11.1 pKd - 1
⤷ pKd 11.1 (Kd 7.9x10-12 M) [1]
Description: Binding affinity for hCD40L in a BIAcore affinity assay.
CD40 ligand Hs Antibody Binding 9.3 pIC50 - 1
⤷ pIC50 9.3 (IC50 4.9x10-10 M) [1]
Description: Measuring inhibition of CD40L binding to CD40.