Synonyms: SL176
Compound class:
Synthetic organic
Comment: SL-176 is a small molecule inhibitor of the metal-dependent Ser/Thr phosphatase PPM1D [1]. It decreases PPM1D enzyme activity in vitro. Exposure of breast cancer cells overexpressing PPM1D induces G2/M arrest and apoptosis. SL-176's antiproliferative effect is independent of TP53 status.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
SL-176 has a more potent antiproliferatice effect on MCF-7 cells compared to GSK2830371 and it inhibits proliferation of p53-null, PPM1D-overexpressing cells (GSK2830371 is inactive in these cells). SL-176 does not inhibit phosphatase activity of PPM1A, PP1 or PP2A in vitro. |
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