Synonyms: CCX 354 | CCX-354 | CCX-354-C
Compound class:
Synthetic organic
Comment: CCX354 is an orally active CCR1 antagonist that was originally developed by Chemocentryx for anti-inflammatory/immunomodulatory potential. The chemical structure is claimed as Example 16 in patent WO2008147815A1 [1]. The structure in the patent resolves to PubChem CID 25016615, which is a tautomeric representation of the claimed structure.
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Bioactivity Comments |
CCX354 inhibits chemotaxis of monocytes with an IC50 ≤100 nM [1]. We have been unable to find unequivocal quantitative data for the affinity of CCX354 for CCR1. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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