GSK2646264   Click here for help

GtoPdb Ligand ID: 10108

Synonyms: compound 44 [PMID: 30249354]
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: GSK2646264 is a skin permeable Syk inhibitor that is being investigated as a topical treatment for skin inflammation [1]. An X-ray crystal structure of GSK2646264 bound to human SYK reveals that it binds the enzyme's aspartate 512 residue which lies within the ribose pocket in the ATP binding site of Syk.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 43.38
Molecular weight 376.22
XLogP 4.35
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1cccc(c1C1=CC2C(C=C1)CCNCC2)OCc1nccc(c1)C
Isomeric SMILES COc1cccc(c1C1=CC2C(C=C1)CCNCC2)OCc1nccc(c1)C
InChI InChI=1S/C24H28N2O2/c1-17-8-13-26-21(14-17)16-28-23-5-3-4-22(27-2)24(23)20-7-6-18-9-11-25-12-10-19(18)15-20/h3-8,13-15,18-19,25H,9-12,16H2,1-2H3
InChI Key CQLSAYKHANAIMX-UHFFFAOYSA-N
Bioactivity Comments
Potential off-targets for which GSK2646264 has the lowest fold selectivity include LCK (39 fold selective), LRRK2 (50 fold selective), GSK3β (63 fold selective) and JAK2 (125 fold selective). GSK2646264 selectivity over the Aurora kinases is improved compared to Syk inhibitors previously identified by the GSK team.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
spleen associated tyrosine kinase Primary target of this compound Hs Inhibitor Inhibition 7.1 pIC50 - 1
⤷ pIC50 7.1 (IC50 7.94x10-8 M) [1]
LCK proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition 5.4 pIC50 - 1
⤷ pIC50 5.4 (IC50 3.981x10-6 M) [1]
leucine rich repeat kinase 2 Hs Inhibitor Inhibition 5.4 pIC50 - 1
⤷ pIC50 5.4 (IC50 3.981x10-6 M) [1]
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 5.3 pIC50 - 1
⤷ pIC50 5.3 (IC50 5.012x10-6 M) [1]
Janus kinase 2 Hs Inhibitor Inhibition 5.0 pIC50 - 1
⤷ pIC50 5.0 (IC50 1x10-5 M) [1]
aurora kinase B Hs Inhibitor Inhibition <4.6 pIC50 - 1
⤷ pIC50 <4.6 (IC50 >2.512x10-5 M) [1]
aurora kinase A Hs Inhibitor Inhibition <4.3 pIC50 - 1
⤷ pIC50 <4.3 (IC50 >5.012x10-5 M) [1]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 4.5 pIC50 - 1
⤷ pIC50 4.5 (IC50 3.162x10-5 M) [1]