Plasmodium falciparum phosphatidylinositol 4-kinase beta
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|
|
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Parasite liver stage assay |
- |
- |
9.0 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
9.0
(IC50 9.2x10-10 M)
Luciferase bioluminescence assay to measure sporozoite invasion (prophylactic activity)
[1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
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Plasmodium falciparum phosphatidylinositol 4-kinase beta
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|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 3.7x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 4.1x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 4.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.3 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.3
(IC50 4.7x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.3 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.3
(IC50 5.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.3 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.3
(IC50 5.4x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.2 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.2
(IC50 5.7x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Parasite liver stage assay |
- |
- |
>8.0 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
>8.0
(IC50 <1x10-8 M)
P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity)
[1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
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Plasmodium falciparum phosphatidylinositol 4-kinase beta
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|
|
|
Parasite dual gamete formation assay (DGFA) |
- |
- |
7.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.1
(IC50 8x10-8 M)
Reports on the functional viability of male and female mature stage V gametocytes
[1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
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Plasmodium falciparum phosphatidylinositol 4-kinase beta
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|
|
|
Parasite gametocyte viability assay |
- |
- |
6.9 – 7.2 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.2
(IC50 6.6x10-8 M)
Parasite late stage (IV-V) gametocyte assay using luciferase reporter line
[1]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
pIC50
6.9
(IC50 1.34x10-7 M)
Parasite early stage (I-III) gametocyte assay using luciferase reporter line
[1]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
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Plasmodium falciparum phosphatidylinositol 4-kinase beta
|
|
|
|
Standard membrane feeding assay (SMFA) |
- |
- |
7.0 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.0
(IC50 9.6x10-8 M)
[1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
|