SID7969543 [Ligand Id: 5423] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL259067
  • RAR-related orphan receptor-α/Nuclear receptor ROR-alpha in Human [ChEMBL: CHEMBL5868] [GtoPdb: 598] [UniProtKB: P35398]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
RAR-related orphan receptor-α/Nuclear receptor ROR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5868] [GtoPdb: 598] [UniProtKB: P35398]
ChEMBL Inhibition of GAL4-tagged RORalpha by luciferase assay B 4.48 pIC50 >33000 nM IC50 Bioorg Med Chem Lett (2008) 18: 2628-2632 [PMID:18374567]
Steroidogenic factor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4666] [GtoPdb: 632] [UniProtKB: Q13285]
ChEMBL Inhibition of GAL4-tagged NR5A1 by luciferase assay B 6.12 pIC50 760 nM IC50 Bioorg Med Chem Lett (2008) 18: 2628-2632 [PMID:18374567]
ChEMBL Inhibition of Gal4-fused human SF1 LBD (198 to 462 residues) expressed in CHO-K1 cells B 7.52 pIC50 30 nM IC50 ACS Med Chem Lett (2020) 11: 365-370 [PMID:32184971]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]