zalcitabine [Ligand Id: 4828] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL853 (Ddc (ddc), Dideoxycytidine, Hivid, NSC-606170, RO 24-2027/000, RO-24-2027000, RO-242027000, Zalcitabine, Zalcitabine (dideoxycytidine,ddc))
  • CXCR4/C-X-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
ChEMBL Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assay F 7.06 pEC50 88 nM EC50 Bioorg Med Chem Lett (2001) 11: 1897-1902 [PMID:11459656]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibitory constant against HIV-1 reverse transcriptase B 7.29 pKi 51 nM Ki J Med Chem (2005) 48: 2695-2700 [PMID:15801860]
ChEMBL Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells. F 7.51 pEC50 31 nM EC50 J Med Chem (2000) 43: 1927-1939 [PMID:10821705]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]