D-glutamic acid [Ligand Id: 4708] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL76232 (E620, Glutamic acid)
  • Glutamate racemase in Lactobacillus fermentum [ChEMBL: CHEMBL3353] [UniProtKB: Q03469]
  • Glutamate racemase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL6078] [UniProtKB: P56068]
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  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
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  • mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421]
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  • mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422]
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  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
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  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
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  • mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glutamate racemase in Lactobacillus fermentum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3353] [UniProtKB: Q03469]
ChEMBL Inhibition towards glutamate racemase from Lactobacillus fermenti was determined and expressed as KI B 4.25 pKi 56000 nM Ki Bioorg Med Chem Lett (1997) 7: 2265-2270
Glutamate racemase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6078] [UniProtKB: P56068]
ChEMBL Inhibition of Helicobacter pylori glutamate racemase B 5.24 pKi 5800 nM Ki Nature (2007) 447: 817-822 [PMID:17568739]
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493]
ChEMBL Tested for inhibition of Specific DL-[H]Ionotropic glutamate receptor AMPA binding to rat brain membranes B 4 pIC50 ~100000 nM IC50 J Med Chem (1983) 26: 901-903 [PMID:6133955]
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450, 451, 452, 453, 454] [UniProtKB: P22756, P42260, P42264, Q01812, Q63273]
ChEMBL In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand B 4.11 pIC50 78000 nM IC50 J Med Chem (1989) 32: 2254-2260 [PMID:2552114]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
ChEMBL Effect on Metabotropic glutamate receptor 1 B 5 pEC50 10000 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421]
ChEMBL Effect on Metabotropic glutamate receptor 2 B 5.4 pEC50 4000 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422]
ChEMBL Effect on Metabotropic glutamate receptor 3 B 5.05 pEC50 9000 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
ChEMBL Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active F 4 pEC50 <100000 nM EC50 J Med Chem (2005) 48: 2534-2547 [PMID:15801843]
ChEMBL Effect on Metabotropic glutamate receptor 4 B 4.92 pEC50 12000 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL Effect on Metabotropic glutamate receptor 5 B 5.36 pEC50 4400 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
ChEMBL Effect on Metabotropic glutamate receptor 6 B 4.7 pEC50 20000 nM EC50 J Med Chem (1997) 40: 3700-3705 [PMID:9357538]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]