omeprazole [Ligand Id: 4279] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1503 (Antra, H 168/68, H-168/68, Losec, Losec mups, Mezzopram, Mopral, NSC-751450, NSC-759192, Omeprazole, Omeran, Prilosec, Zanprol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247] | ||||||||
| ChEMBL | Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay | F | 4.85 | pEC50 | 14000 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 5451-5455 [PMID:18818070] |
| Endo-beta-N-acetylglucosaminidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3] | ||||||||
| ChEMBL | Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreated for 15 mins followed by substrate addition after 90 mins by SDS-PAGE analysis | B | 4.6 | pIC50 | 25000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2962-2966 [PMID:28512024] |
| fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327] | ||||||||
| ChEMBL | Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay | B | 5.47 | pKi | 3400 | nM | Ki | J Med Chem (2015) 58: 778-784 [PMID:25513712] |
| ChEMBL | Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay | B | 4.53 | pIC50 | 29600 | nM | IC50 | J Med Chem (2015) 58: 778-784 [PMID:25513712] |
| glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417] | ||||||||
| ChEMBL | Inhibition of GSTO1-1 (unknown origin) by enzymatic assay | B | 5.34 | pIC50 | 4600 | nM | IC50 | J Med Chem (2018) 61: 7448-7470 [PMID:29652143] |
| NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760] | ||||||||
| ChEMBL | Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using ADMA as substrate assessed as decrease in citrulline production after 4 hrs by colorimetric method | B | 4.7 | pIC50 | 20000 | nM | IC50 | WO-2014160947-A1. Dimethylarginine Dimethylaminohydrolase inhibitors and methods of use thereof (2014) |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model | B | 4.01 | pIC50 | 97200 | nM | IC50 | J Med Chem (2002) 45: 5671-5686 [PMID:12477351] |
| ChEMBL | Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model | B | 4.04 | pIC50 | 91200 | nM | IC50 | J Med Chem (2002) 45: 5671-5686 [PMID:12477351] |
| ChEMBL | Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model | B | 4.05 | pIC50 | 89000 | nM | IC50 | J Med Chem (2002) 45: 5671-5686 [PMID:12477351] |
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells | F | 4.75 | pIC50 | 17700 | nM | IC50 | Naunyn Schmiedebergs Arch Pharmacol (2001) 364: 551-557 [PMID:11770010] |
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells | F | 6.17 | pIC50 | 680 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.12 | pIC50 | 76000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection | F | 4.3 | pIC50 | >50000 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| ChEMBL | HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection | F | 4.3 | pIC50 | >50000 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
| ChEMBL | DNDI: Malaria in Vitro, 72 hour | F | 4.88 | pIC50 | 13230 | nM | IC50 | Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning |
| ATP4A/ATP4B/Potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095173] [GtoPdb: 849, 851] [UniProtKB: P20648, P51164] | ||||||||
| ChEMBL | Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparations | B | 4.65 | pIC50 | 22400 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2819-2822 [PMID:10522698] |
| ChEMBL | Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4) | B | 5.42 | pIC50 | 3800 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1909-1912 [PMID:9873457] |
| ChEMBL | In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (1988) 31: 1215-1220 [PMID:2836591] |
| ChEMBL | In vitro evaluation for the inhibition of H+/K+ ATPase at pH < 3 in the gastric glands of isolated rabbit stomach. | B | 6.3 | pIC50 | 501.19 | nM | IC50 | J Med Chem (1992) 35: 1049-1057 [PMID:1313110] |
| ChEMBL | Inhibition of [14C]aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells | F | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (1997) 40: 313-321 [PMID:9022797] |
| ChEMBL | Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5' -monophosphate (dcAMP) | F | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (1988) 31: 1778-1785 [PMID:2842503] |
| ChEMBL | Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine | F | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (1988) 31: 1778-1785 [PMID:2842503] |
| Potassium-transporting ATPase in Pig (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095228] [UniProtKB: P18434, P19156] | ||||||||
| ChEMBL | Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPase | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (1991) 34: 1049-1062 [PMID:1848293] |
| ChEMBL | In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Med Chem (1996) 39: 596-604 [PMID:8558532] |
| sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] [UniProtKB: P05023, P05026, P13637, P14415, P50993, P54709, P54710, Q13733] | ||||||||
| ChEMBL | In vitro evaluation for its ability to inhibit the Na+/K+ ATPase at pH 7.4. | B | 4.5 | pIC50 | 31622.78 | nM | IC50 | J Med Chem (1992) 35: 1049-1057 [PMID:1313110] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
