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SLC47 family of multidrug and toxin extrusion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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These proton:organic cation exchangers are predicted to have 13 TM segments [11] and are suggested to be responsible for excretion of many drugs in the liver and kidneys [1].

Transporters

1216
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Targets of relevance to immunopharmacology are highlighted in blue

MATE1 (Multidrug and toxin extrusion / SLC47A1) C Show summary »


Target Id 1216
Nomenclature Multidrug and toxin extrusion
Systematic nomenclature SLC47A1
Common abbreviation MATE1
Previous and unofficial names H+/organic cation antiporter variant 1 | H+/organic cation antiporter variant 2 | solute carrier family 47, member 1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | solute carrier family 47
Genes SLC47A1 (Hs), Slc47a1 (Mm), Slc47a1 (Rn)
Ensembl ID ENSG00000142494 (Hs), ENSMUSG00000010122 (Mm), ENSRNOG00000002355 (Rn)
UniProtKB AC Q96FL8 (Hs), Q8K0H1 (Mm), Q5I0E9 (Rn)
Bioparadigms SLC Tables SLC47A1 (Hs)
Endogenous substrates
creatine [7]
thiamine [7]
Substrates
quinidine [7]
paraquat [2]
cephradine [7]
cephalexin [7]
cimetidine pKm 3.8 [5,7]
metformin pKm 3.1 [7]
Sub/family-selective inhibitors
pyrimethamine pKi 7.1 [3]
cimetidine pKi 6.0 [9]
Labelled ligands
[14C]metformin [7-8]
[14C]TEA [6,8]

MATE2-K (MATE2 / SLC47A2) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.