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Your search for Alzheimer's returned 167 results

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Target: programmed cell death 1 (CD279) (Other immune checkpoint proteins, CD molecules)
Mutations/pathophysiology - disease: Alzheimer disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Mutations/pathophysiology - role: Alzheimer's disease anti-PD1 antibody treatment was used to induce immune checkpoint blockade. The biological
Receptor Immuno Comment: Alzheimer's disease (AD): In mouse models of AD anti-PD-1 antibody treatment was used
Disease: Alzheimer disease
Disease Name: Alzheimer disease
Disease Synonym: Alzheimer's disease
Pathophysiology comments: Alzheimer's disease. Inhbition of C5aR, through oral administration of PMX205, in these models reduces
Pathophysiology role: Alzheimer's disease anti-PD1 antibody treatment was used to induce immune checkpoint blockade. The biological
Pathophysiology role: neurons and may be a potential therapeutic target for the treatment of Alzheimer's disease
Ligand: neflamapimod
Comments: compound is being repurposed since the p38alpha mechanism may modulate Alzheimer's specific inflammatory processes .
Clinical use: Alzheimer's disease in June 2015. These trials, NCT02423200 and NCT02423122, have now been completed
Immuno Ligand Comments: Alzheimer's disease, as predicted by preclinical assessment in a mouse model of the disease
Target: C5a1 receptor (Complement peptide receptors)
Mutations/pathophysiology - disease: Alzheimer disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Mutations/pathophysiology - comment: Alzheimer's disease. Inhbition of C5aR, through oral administration of PMX205, in these models reduces
Target: NLRP1 (NOD-like receptor family)
Comment: cancer , and evidence that suggests that NLRP1 and NLRP3 inflammasomes are activated in Alzheimer's disease .
Mutations/pathophysiology - disease: Alzheimer disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Disease: Alzheimer disease 4
Disease Name: Alzheimer disease 4
Disease Synonym: Early-onset autosomal dominant Alzheimer disease
Disease Synonym: Alzheimer's disease
Disease: Alzheimer disease 3
Disease Name: Alzheimer disease 3
Disease Synonym: Early-onset autosomal dominant Alzheimer disease
Disease Synonym: Alzheimer's disease
Target: GPR3 (Class A Orphans)
Consequences of altering gene expression: implicated in Alzheimer's disease and is elevated in the sporadic Alzheimer's disease brain.
Consequences of altering gene expression: accumulation of the amyloid-beta peptide in vitro and in an Alzheimer's disease mouse model
Mutations/pathophysiology - disease: Alzheimer disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Mutations/pathophysiology - role: neurons and may be a potential therapeutic target for the treatment of Alzheimer's disease
Target: Cav1.2 (Voltage-gated calcium channels (CaV))
Gene Expression and Pathophysiology: Upregulation in reactive astrocytes around amyloid plaques in mouse Alzheimer models
Gene Expression and Pathophysiology: Alzheimer's disease
Ligand: rilapladib
Comments: Alzheimer's disease. Compounds of different chemotypes are being explored as tools to further optimise
Clinical use: compound to treat Alzheimer's disease has been assessed in a Phase 2a study (NCT01428453).

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