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GPR27

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Target not currently curated in GtoImmuPdb

Target id: 97

Nomenclature: GPR27

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 375 3p13 GPR27 G protein-coupled receptor 27 3-4
Mouse 7 379 6 D3 Gpr27 G protein-coupled receptor 27
Rat 7 377 4q34 Gpr27 G protein-coupled receptor 27
Previous and Unofficial Names Click here for help
super conserved receptor expressed in brain 1 | SREB1
Database Links Click here for help
Specialist databases
GPCRdb gpr27_human (Hs), gpr27_mouse (Mm), gpr27_rat (Rn)
Other databases
Alphafold Q9NS67 (Hs), O54897 (Mm), Q9JJH3 (Rn)
ChEMBL Target CHEMBL4523923 (Hs)
Ensembl Gene ENSG00000170837 (Hs), ENSMUSG00000072875 (Mm), ENSRNOG00000010880 (Rn)
Entrez Gene 2850 (Hs), 14761 (Mm), 65275 (Rn)
Human Protein Atlas ENSG00000170837 (Hs)
KEGG Gene hsa:2850 (Hs), mmu:14761 (Mm), rno:65275 (Rn)
OMIM 605187 (Hs)
Pharos Q9NS67 (Hs)
RefSeq Nucleotide NM_018971 (Hs), NM_008158 (Mm), NM_023099 (Rn)
RefSeq Protein NP_061844 (Hs), NP_032184 (Mm), NP_075587 (Rn)
UniProtKB Q9NS67 (Hs), O54897 (Mm), Q9JJH3 (Rn)
Wikipedia GPR27 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Comments:  Alteration of gene expression affects stimulation of IP3 [1]
References: 
Tissue Distribution Click here for help
Brain (caudate nucleus, putamen, hippocampus, subthalamic nucleus), ovary, testis, heart, prostate, pancreas, peripheral leukocytes
Species:  Human
Technique:  Northern Blot
References:  3
Cerebral cortex (piriform cortex, anterior cingulate, frontoparietal, somatosensory areas); caudate putamen, nucleus accumbens; hypothalamic nuclei (suprachiasmatic, supraoptic, ventromedial, paraventricular, arcuate)
Species:  Rat
Technique:  in situ hybridisation
References:  4
Whole brain, hippocampus, striatum, frontal cortex, thalamus, pons, hypothalamus
Species:  Rat
Technique:  Northern Blot
References:  4
Tissue Distribution Comments
GPR27 has been detected at higher levels in fetal brains than in adult brains, suggesting a role in neural plasticity. The receptor is highly conserved amongst mammals, with expression seen in grey matter areas of the monkey brain (hippocampal dentate gyrus and supraoptic nucleus of the hypothalamus) as demonstrated by in situ hybridisation [2].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Click here for help
Overexpression of Gpr27 increases inositol trisphosphate levels with no effect on cAMP
Species:  Mouse
Tissue:  MIN6 cells
Technique:  Gene overexpression
References:  1
Knockdown of Gpr27 reduces endogenous mouse insulin promotor activity and glucose stimulated insulin secretion
Species:  Mouse
Tissue:  Pancreatic β cells
Technique:  RNA interference
References:  1
Clinically-Relevant Mutations and Pathophysiology Comments
GPR27 mapped to a 15Mb constitutional de novo interstitial deletion of chromosome 3 shown to cause developmental delay and congenital anomalies. Deletion is also seen along with FOXP1, EIF4E3 and PROK2 resulting in speech delay, contractures, hypertonia and blepharophimosis, although the physiological role (if any) of GPR27 is unknown [5-6].

References

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1. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. (2012) An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet, 8 (1): e1002449. [PMID:22253604]

2. Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, Lipska BK, Weinberger DR, Kleinman JE. (2005) A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res Mol Brain Res, 138 (1): 58-69. [PMID:15893849]

3. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun, 272 (2): 576-82. [PMID:10833454]

4. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski Jr LF, George SR. (1998) Discovery of three novel G-protein-coupled receptor genes. Genomics, 47 (2): 310-3. [PMID:9479505]

5. Pariani MJ, Spencer A, Graham JM, Rimoin DL. (2009) A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. Eur J Med Genet, 52 (2-3): 123-7. [PMID:19332160]

6. Petek E, Windpassinger C, Simma B, Mueller T, Wagner K, Kroisel PM. (2003) Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies. J Hum Genet, 48 (6): 283-7. [PMID:12836054]

Contributors

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