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ABCB3

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 770

Nomenclature: ABCB3

Abbreviated Name: TAP2

Systematic Nomenclature: ABCB3

Family: ABCB subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 9 686 6p21.32 TAP2 transporter 2, ATP binding cassette subfamily B member
Mouse 9 702 17 17.98 cM Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Rat 9 703 20p12 Tap2 transporter 2, ATP binding cassette subfamily B member
Previous and Unofficial Names Click here for help
Antigen peptide transporter 2 (APT2) | peptide supply factor 2 (PSF-2) | Peptide transporter TAP2 | ATP-binding cassette sub-family B member 3 | Cim | Transporter 2 ABC (ATP binding cassette) | Ham2 | MTP2 | peptide transporter involved in antigen processing 2 | RING11 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | transporter 2 | transporter 2, ATP binding cassette subfamily B member
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
TAP1 (ABCB2) and TAP2 (ABCB3) form a transporter that plays an important role in antigen presentation by major histocompatibility complex class I (MHCI) molecules in the adaptive immune response [1].
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Inflammation

References

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1. Seyffer F, Tampé R. (2015) ABC transporters in adaptive immunity. Biochim Biophys Acta, 1850 (3): 449-60. [PMID:24923865]

Contributors

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