Quaternary Structure: Complexes

ENaCαβγ

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	2	649	16p12.2	SCNN1G	sodium channel epithelial 1 subunit gamma	1
Mouse	2	655	7 65.07 cM	Scnn1g	sodium channel, nonvoltage-gated 1 gamma	1
Rat	2	650	1q36	Scnn1g	sodium channel epithelial 1 subunit gamma	1

Previous and Unofficial Names

SCNEG | amiloride sensitive sodium channel gamma1 subunit | ENaC | epithelial Na(+) channel subunit gamma | epithelial sodium channel gamma subunit | gamma-ENaC | gamma-NaCH | ENaC gamma | sodium channel, non-voltage-gated 1, gamma subunit | sodium channel, non voltage gated 1 gamma subunit | sodium channel | sodium channel epithelial 1 gamma subunit

Database Links
Alphafold	P51170 (Hs), Q9WU39 (Mm), P37091 (Rn)
ChEMBL Target	CHEMBL1628484 (Hs)
DrugBank Target	P51170 (Hs)
Ensembl Gene	ENSG00000166828 (Hs), ENSMUSG00000000216 (Mm), ENSRNOG00000017842 (Rn)
Entrez Gene	6340 (Hs), 20278 (Mm), 24768 (Rn)
Human Protein Atlas	ENSG00000166828 (Hs)
KEGG Gene	hsa:6340 (Hs), mmu:20278 (Mm), rno:24768 (Rn)
OMIM	600761 (Hs)
Pharos	P51170 (Hs)
UniProtKB	P51170 (Hs), Q9WU39 (Mm), P37091 (Rn)
Wikipedia	SCNN1G (Hs)

Natural/Endogenous Ligands
sodium

Clinically-Relevant Mutations and Pathophysiology
Disease:  Bronchiectasis with or without elevated sweat chloride 3; BESC3 Synonyms: Bronchiectasis [Disease Ontology: DOID:9563] Idiopathic bronchiectasis [Orphanet: ORPHA60033] Disease Ontology: DOID:9563 OMIM: 613071 Orphanet: ORPHA60033
Disease:  Liddle syndrome; LIDLS Disease Ontology: DOID:0050477 OMIM: 177200 Orphanet: ORPHA526
Disease:  Pseudohypoaldosteronism, type I, autosomal recessive; PHA1B Synonyms: Autosomal recessive pseudohypoaldosteronism type 1 [Orphanet: ORPHA171876] Generalized pseudohypoaldosteronism type 1 [Orphanet: ORPHA171876] Pseudohypoaldosteronism [Disease Ontology: DOID:4479] Disease Ontology: DOID:4479 OMIM: 264350 Orphanet: ORPHA171876