RAMP2

Target id: 52

Nomenclature: RAMP2

Quaternary Structure: Complexes
AMY₂ receptor
AM₁ receptor

Gene and Protein Information
Receptor activity modifying protein
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	References
Human	1	175	17q12-q21.1	RAMP2	receptor activity modifying protein 2	1,3
Mouse	1	189	11 D	Ramp2	receptor (calcitonin) activity modifying protein 2	1
Rat	1	182	10q32.1	Ramp2	receptor activity modifying protein 2

Previous and Unofficial Names
receptor activity modifying protein 2
receptor (G protein-coupled) activity modifying protein 2

Previous and Unofficial Names

receptor activity modifying protein 2

receptor (G protein-coupled) activity modifying protein 2

Database Links
Alphafold	O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn)
ChEMBL Target	CHEMBL2109232 (Hs), CHEMBL2364173 (Hs)
DrugBank Target	O60895 (Hs)
Ensembl Gene	ENSG00000131477 (Hs), ENSMUSG00000001240 (Mm), ENSRNOG00000020441 (Rn)
Entrez Gene	10266 (Hs), 54409 (Mm), 58966 (Rn)
Human Protein Atlas	ENSG00000131477 (Hs)
KEGG Gene	hsa:10266 (Hs), mmu:54409 (Mm), rno:58966 (Rn)
OMIM	605154 (Hs)
Pharos	O60895 (Hs)
RefSeq Nucleotide	NM_005854 (Hs), NM_019444 (Mm), NM_031646 (Rn)
RefSeq Protein	NP_005845 (Hs), NP_062317 (Mm), NP_113834 (Rn)
UniProtKB	O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn)
Wikipedia	RAMP2 (Hs)

Protein Comments
In situ hybridisation studies of the rat brain have showed RAMP2 mRNA to be located predominantly in the hypothalamus and amygdala [4]. Immunochemistry shows RAMP2 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5]. Northern blotting shows mouse RAMP2 mRNA to be located predominantly in the brain, lung, heart and skeletal muscle [2].

References

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1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet, 90 (1-2): 115-8. [PMID:11060459]

2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]

3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]

4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]

5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab, 22 (5): 620-9. [PMID:11973435]