Top ▲

GABAA receptor β1 subunit

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 410

Nomenclature: GABAA receptor β1 subunit

Family: GABAA receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 474 4p12 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 2-3
Mouse 4 474 5 38.18 cM Gabrb1 gamma-aminobutyric acid type A receptor subunit beta 1 1
Rat 4 474 14p11 Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 4
Previous and Unofficial Names Click here for help
gamma-aminobutyric acid receptor subunit beta-1 | Gabrb-1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor beta1 subunit | gamma-aminobutyric acid type A receptor beta 1 subunit
Database Links Click here for help
Alphafold P18505 (Hs), P50571 (Mm), P15431 (Rn)
CATH/Gene3D 2.70.170.10
ChEMBL Target CHEMBL4558 (Hs), CHEMBL2094133 (Mm), CHEMBL1907607 (Rn)
DrugBank Target P18505 (Hs), P18505 (Hs)
Ensembl Gene ENSG00000163288 (Hs), ENSMUSG00000029212 (Mm), ENSRNOG00000002327 (Rn)
Entrez Gene 2560 (Hs), 14400 (Mm), 25450 (Rn)
Human Protein Atlas ENSG00000163288 (Hs)
KEGG Gene hsa:2560 (Hs), mmu:14400 (Mm), rno:25450 (Rn)
OMIM 137190 (Hs)
Pharos P18505 (Hs)
RefSeq Nucleotide NM_000812 (Hs), NM_008069 (Mm), NM_012956 (Rn)
RefSeq Protein NP_000803 (Hs), NP_032095 (Mm), NP_037088 (Rn)
UniProtKB P18505 (Hs), P50571 (Mm), P15431 (Rn)
Wikipedia GABRB1 (Hs)
Natural/Endogenous Ligands Click here for help
GABA

Download all structure-activity data for this target as a CSV file go icon to follow link

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent

References

Show »

1. Kamatchi GL, Kofuji P, Wang JB, Fernando JC, Liu Z, Mathura JR, Burt DR. (1995) GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim Biophys Acta, 1261 (1): 134-42. [PMID:7893750]

2. Kirkness EF, Kusiak JW, Fleming JT, Menninger J, Gocayne JD, Ward DC, Venter JC. (1991) Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). Genomics, 10 (4): 985-95. [PMID:1655634]

3. Schofield PR, Pritchett DB, Sontheimer H, Kettenmann H, Seeburg PH. (1989) Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. FEBS Lett, 244 (2): 361-4. [PMID:2465923]

4. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. (1989) GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J, 8 (6): 1665-70. [PMID:2548852]

Contributors

Show »

How to cite this page