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ACKR1

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 316

Nomenclature: ACKR1

Family: Chemokine receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 336 1q23.2 ACKR1 atypical chemokine receptor 1 (Duffy blood group)
Mouse 7 334 1 80.33 cM Ackr1 atypical chemokine receptor 1 (Duffy blood group)
Rat - - 13q24 Ackr1 atypical chemokine receptor 1
Previous and Unofficial Names Click here for help
Duffy antigen/chemokine receptor | atypical chemokine receptor 1 | CD234 | Dfy | Duffy blood group, atypical chemokine receptor | Darc
Database Links Click here for help
Specialist databases
GPCRdb ackr1_human (Hs), ackr1_mouse (Mm)
Other databases
Alphafold Q16570 (Hs), Q9QUI6 (Mm)
ChEMBL Target CHEMBL2321626 (Hs)
Ensembl Gene ENSG00000213088 (Hs), ENSMUSG00000037872 (Mm), ENSRNOG00000069330 (Rn)
Entrez Gene 2532 (Hs), 13349 (Mm)
Human Protein Atlas ENSG00000213088 (Hs)
KEGG Gene hsa:2532 (Hs), mmu:13349 (Mm)
OMIM 110700 (Hs)
Pharos Q16570 (Hs)
RefSeq Nucleotide NM_002036 (Hs), NM_010045 (Mm)
RefSeq Protein NP_002027 (Hs), NP_034175 (Mm)
UniProtKB Q16570 (Hs), Q9QUI6 (Mm)
Wikipedia ACKR1 (Hs)
Endogenous ligands (Human)
CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583)
Immunopharmacology Comments
ACKR1 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. Studies in ACKR1 null mice, and analysis of ACKR1 SNPs in asthmatic patients with poorly controlled symptoms, suggest a role for this cytokine receptor in the temporal regulation of asthma pathophysiology and symptoms [1].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  ACKR1 may play a role in the temporal regulation of asthma pathophysiology and symptoms.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Click here for help
Mice with targeted disruption of the ACKR1 gene show increased airway hyperresponsiveness to allergen challenge at 24 hours (post last exposure) compared to WT mice. By 7 days post exposure the hyperresponsiveness had resolved in ACKR1 deficient mice but not in WT mice.
Species:  Mouse
Tissue:  Airways.
Technique: 
References:  1
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0000065 abnormal bone marrow cavity morphology PMID: 17416748 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0000130 abnormal cancellous bone morphology PMID: 17416748 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0008721 abnormal chemokine level PMID: 12646177 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd		 MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Cxcl5tm1Gscw|Darctm1Scp Cxcl5tm1Gscw/Cxcl5tm1Gscw,Darctm1Scp/Darctm1Scp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6		 MGI:1096868  MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0001764 abnormal homeostasis PMID: 12646177 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0010120 increased bone mineral density PMID: 17416748 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd * C57BL/6		 MGI:1097689  MP:0001846 increased inflammatory response PMID: 10961863 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Plasmodium vivax malaria
Disease Ontology: DOID:12978
OMIM: 611162
Role:  Variation in the ACKR1 gene can result in protection against Plasmodium vivax malaria.
Biologically Significant Variant Comments
The Duffy blood group system, associated with complete resistance to the malarial parasite Plasmodium vivax, and white blood cell count as a quantitative trait are based on variation in the DARC gene. For more information see OMIM entries 110700 and 611862.

References

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1. Chapman DG, Mougey EB, Van der Velden JL, Lahue KG, Aliyeva M, Daphtary N, George KL, Hoffman SM, Schneider RW, Tracy RP et al.. (2017) The Duffy antigen receptor for chemokines regulates asthma pathophysiology. Clin Exp Allergy, 47 (9): 1214-1222. [PMID:28471517]

Contributors

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