Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1056	10q23.33	KIF11	kinesin family member 11
Mouse	-	1052	19 C2	Kif11	kinesin family member 11
Rat	-	1056	1q53	Kif11	kinesin family member 11

Previous and Unofficial Names

BimC | Eg5

Database Links
Alphafold	P52732 (Hs), Q6P9P6 (Mm)
CATH/Gene3D	3.40.850.10
ChEMBL Target	CHEMBL4581 (Hs)
Ensembl Gene	ENSG00000138160 (Hs), ENSMUSG00000012443 (Mm), ENSRNOG00000056069 (Rn)
Entrez Gene	3832 (Hs), 16551 (Mm), 171304 (Rn)
Human Protein Atlas	ENSG00000138160 (Hs)
KEGG Gene	hsa:3832 (Hs), mmu:16551 (Mm), rno:171304 (Rn)
OMIM	148760 (Hs)
Pharos	P52732 (Hs)
RefSeq Nucleotide	NM_004523 (Hs), NM_010615 (Mm), NM_001169112 (Rn)
RefSeq Protein	NP_004514 (Hs), NP_034745 (Mm), NP_001162583 (Rn)
UniProtKB	P52732 (Hs), Q6P9P6 (Mm)
Wikipedia	KIF11 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference AZD4877 Hs Inhibition 8.7 pIC50 1 ⤷ pIC50 8.7 (IC50 2x10-9 M) [1] Description: Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11

Immuno Process Associations

Immuno Process:  Antigen presentation

Clinically-Relevant Mutations and Pathophysiology
Disease:  Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; MCLMR Synonyms: Microcephaly - lymphedema - chorioretinopathy [Orphanet: ORPHA2526] OMIM: 152950 Orphanet: ORPHA2526