Target has curated data in GtoImmuPdb
Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Selected 3D Structures
- Natural/Endogenous Ligands
- Rank order lists
- Agonists
- Antagonists
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Consequences of Altering Gene Expression
- Phenotypes, Alleles and Disease Models
- General Comments
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 353 | 19p13.2 | S1PR2 | sphingosine-1-phosphate receptor 2 | |
| Mouse | 7 | 352 | 9 7.68 cM | S1pr2 | sphingosine-1-phosphate receptor 2 | |
| Rat | 7 | 352 | 8q13 | S1pr2 | sphingosine-1-phosphate receptor 2 | |
| Previous and Unofficial Names |
| edg5 | Gpcr13 | S1P receptor 2 | endothelial differentiation G protein-coupled receptor 5 | G protein-coupled receptor 13 | GPCR18 |
| Database Links |
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| Specialist databases | |
| GPCRdb | s1pr2_human (Hs), s1pr2_mouse (Mm), s1pr2_rat (Rn) |
| Other databases | |
| Alphafold | O95136 (Hs), P52592 (Mm), P47752 (Rn) |
| ChEMBL Target | CHEMBL2955 (Hs), CHEMBL3616360 (Rn) |
| Ensembl Gene | ENSG00000267534 (Hs), ENSMUSG00000043895 (Mm), ENSRNOG00000020653 (Rn) |
| Entrez Gene | 9294 (Hs), 14739 (Mm), 29415 (Rn) |
| Human Protein Atlas | ENSG00000267534 (Hs) |
| KEGG Gene | hsa:9294 (Hs), mmu:14739 (Mm), rno:29415 (Rn) |
| OMIM | 605111 (Hs) |
| Pharos | O95136 (Hs) |
| RefSeq Nucleotide | NM_004230 (Hs), NM_010333 (Mm), NM_017192 (Rn) |
| RefSeq Protein | NP_004221 (Hs), NP_034463 (Mm), NP_058888 (Rn) |
| UniProtKB | O95136 (Hs), P52592 (Mm), P47752 (Rn) |
| Wikipedia | S1PR2 (Hs) |
| Selected 3D Structures |
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| Natural/Endogenous Ligands |
| dihydrosphingosine 1-phosphate |
| sphingosine 1-phosphate |
| sphingosylphosphorylcholine |
| Comments: Sphingosine 1-phosphate exhibits greater potency than sphingosylphosphorylcholine |
| Potency order of endogenous ligands |
| sphingosine 1-phosphate > dihydrosphingosine 1-phosphate [2,28] |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific agonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific antagonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S1P d20:1 is reported to inhibit S1P-inudced COX-2 expression via S1P2 in glioblastoma cell line LN299 [41]. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| Activation of S1P2R has pro-inflammatory effects (e.g. mast cell degranulation, regulation of pro-inflammatory cytokine production, and cytokine and chemokine release [21,31]. In human cord blood mast cells, S1P2R positively regulates allergen-induced degranulation and chemokine release [29,33]. |
| Cell Type Associations | ||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
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Gs family Gq/G11 family G12/G13 family |
Adenylyl cyclase stimulation Phospholipase C stimulation Calcium channel |
| Comments: Activation of Rho, MAPK, and phosphorylation of MLC [8]. | |
| References: 8,16 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| S1P2 receptor has been shown to be a specific receptor for the central nervous system membrane protein Nogo-A-Δ20 [17]. |
References
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