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bone morphogenetic protein 1

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Target not currently curated in GtoImmuPdb

Target id: 2333

Nomenclature: bone morphogenetic protein 1

Family: M12: Astacin/Adamalysin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 986 8p21.3 BMP1 bone morphogenetic protein 1
Mouse - 991 14 36.32 cM Bmp1 bone morphogenetic protein 1
Rat - 990 15p11 Bmp1 bone morphogenetic protein 1
Previous and Unofficial Names Click here for help
mammalian tolloid protein | PCOLC | Pcp | procollagen C-proteinase | Tld | procollagen C-endopeptidase
Database Links Click here for help
Specialist databases
MEROPS M12.005 (Hs)
Other databases
Alphafold P13497 (Hs), P98063 (Mm)
BRENDA 3.4.24.19
CATH/Gene3D 2.60.120.290, 3.40.390.10
ChEMBL Target CHEMBL3898 (Hs)
Ensembl Gene ENSG00000168487 (Hs), ENSMUSG00000022098 (Mm), ENSRNOG00000010890 (Rn)
Entrez Gene 649 (Hs), 12153 (Mm), 83470 (Rn)
Human Protein Atlas ENSG00000168487 (Hs)
KEGG Enzyme 3.4.24.19
KEGG Gene hsa:649 (Hs), mmu:12153 (Mm), rno:83470 (Rn)
OMIM 112264 (Hs)
Orphanet ORPHA287069 (Hs)
Pharos P13497 (Hs)
RefSeq Nucleotide NM_001199 (Hs), NM_006129 (Hs), NM_009755 (Mm), NM_031323 (Rn)
RefSeq Protein NP_001190 (Hs), NP_006120 (Hs), NP_033885 (Mm), NP_112613 (Rn)
UniProtKB P13497 (Hs), P98063 (Mm)
Wikipedia BMP1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.19

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2 [PMID: 11934595] Small molecule or natural product Ligand has a PDB structure Hs Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 2x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Osteogenesis imperfecta, type XIII
OMIM: 614856

References

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1. Dankwardt SM, Abbot SC, Broka CA, Martin RL, Chan CS, Springman EB, Van Wart HE, Walker KA. (2002) Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains. Bioorg Med Chem Lett, 12 (8): 1233-5. [PMID:11934595]

How to cite this page

M12: Astacin/Adamalysin: bone morphogenetic protein 1. Last modified on 14/07/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2333.