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serine/threonine-protein kinase MST4

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Target not currently curated in GtoImmuPdb

Target id: 2287

Nomenclature: serine/threonine-protein kinase MST4

Abbreviated Name: MST4

Family: YSK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 Xq26.2 STK26 serine/threonine kinase 26
Mouse - 416 X A5 Stk26 serine/threonine kinase 26
Rat - 416 Xq36 Stk26 serine/threonine kinase 26
Previous and Unofficial Names Click here for help
Mst3 and SOK1-related kinase | serine/threonine-protein kinase MASK | mammalian STE20-like protein kinase 4 | 2610018G03Rik | RIKEN cDNA 2610018G03 gene | Mst4 | serine/threonine protein kinase MST4 | serine/threonine protein kinase 26
Database Links Click here for help
Alphafold Q9P289 (Hs), Q99JT2 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5941 (Hs)
Ensembl Gene ENSG00000134602 (Hs), ENSMUSG00000031112 (Mm), ENSRNOG00000007879 (Rn)
Entrez Gene 51765 (Hs), 70415 (Mm), 317589 (Rn)
Human Protein Atlas ENSG00000134602 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:51765 (Hs), mmu:70415 (Mm), rno:317589 (Rn)
Pharos Q9P289 (Hs)
RefSeq Nucleotide NM_016542 (Hs), NM_133729 (Mm), NM_001191736 (Rn)
RefSeq Protein NP_057626 (Hs), NP_598490 (Mm), NP_001178665 (Rn)
UniProtKB Q9P289 (Hs), Q99JT2 (Mm)
Wikipedia STK26 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2-3
Key to terms and symbols Click column headers to sort
Target used in screen: MST4
Ligand Sp. Type Action Value Parameter
neratinib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 8.1 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.4 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.6 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.5 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.3 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx

Reference: ...1
Key to terms and symbols Click column headers to sort
Target used in screen: nd/MSTR4
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 4.4
Cdk1/2 inhibitor III Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 4.5
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.9
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 10.8
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 20.5
PKCbeta inhibitor Small molecule or natural product Hs Inhibitor Inhibition 22.2
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 23.8
JAK3 inhibitor VI Small molecule or natural product Hs Inhibitor Inhibition 27.3
GF109203X Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 37.2
Gö 6983 Small molecule or natural product Hs Inhibitor Inhibition 40.4
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YSK subfamily: serine/threonine-protein kinase MST4. Last modified on 01/08/2014. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2287.