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serine/threonine kinase 25

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Target not currently curated in GtoImmuPdb

Target id: 2218

Nomenclature: serine/threonine kinase 25

Abbreviated Name: YSK1

Family: YSK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 426 2q37.3 STK25 serine/threonine kinase 25
Mouse - 426 1 47.25 cM Stk25 serine/threonine kinase 25 (yeast)
Rat - 426 9 q36 Stk25 serine/threonine kinase 25
Previous and Unofficial Names Click here for help
SOK1
Database Links Click here for help
Alphafold O00506 (Hs), Q9Z2W1 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5552 (Hs)
Ensembl Gene ENSG00000115694 (Hs), ENSMUSG00000026277 (Mm), ENSRNOG00000018181 (Rn)
Entrez Gene 10494 (Hs), 59041 (Mm), 373542 (Rn)
Human Protein Atlas ENSG00000115694 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:10494 (Hs), mmu:59041 (Mm), rno:373542 (Rn)
OMIM 602255 (Hs)
Pharos O00506 (Hs)
RefSeq Nucleotide NM_006374 (Hs), NM_021537 (Mm), NM_184049 (Rn)
RefSeq Protein NP_006365 (Hs), NP_067512 (Mm), NP_908938 (Rn)
UniProtKB O00506 (Hs), Q9Z2W1 (Mm)
Wikipedia STK25 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of human YSK1 (Yeast Sps1-Ste20-Related Kinase 1)
PDB Id:  2XIK
Resolution:  1.97Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2-3
Key to terms and symbols Click column headers to sort
Target used in screen: YSK1
Ligand Sp. Type Action Value Parameter
neratinib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 7.9 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.0 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.7 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx

Reference: ...1
Key to terms and symbols Click column headers to sort
Target used in screen: nd/STK25(YSK1)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 3.2
Cdk1/2 inhibitor III Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.2
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 10.1
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 30.7
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 34.4
JAK3 inhibitor VI Small molecule or natural product Hs Inhibitor Inhibition 47.2
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 55.0
Gö 6983 Small molecule or natural product Hs Inhibitor Inhibition 55.7
SU11652 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 56.1
PKCbeta inhibitor Small molecule or natural product Hs Inhibitor Inhibition 63.1
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YSK subfamily: serine/threonine kinase 25. Last modified on 26/03/2013. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2218.