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SH3 domain binding kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2193

Nomenclature: SH3 domain binding kinase 1

Abbreviated Name: SBK

Family: NKF1 family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 424 16p12.1 SBK1 SH3 domain binding kinase 1
Mouse - 417 7 F3 Sbk1 SH3-binding kinase 1
Rat - 417 1q36 Sbk1 SH3 domain binding kinase 1
Previous and Unofficial Names Click here for help
SH3-binding domain kinase 1
Database Links Click here for help
Alphafold Q52WX2 (Hs), Q8QZX0 (Mm), Q9Z335 (Rn)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL1163129 (Hs)
Ensembl Gene ENSG00000188322 (Hs), ENSMUSG00000042978 (Mm), ENSRNOG00000067387 (Rn)
Entrez Gene 388228 (Hs), 104175 (Mm), 113907 (Rn)
Human Protein Atlas ENSG00000188322 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:388228 (Hs), mmu:104175 (Mm), rno:113907 (Rn)
Pharos Q52WX2 (Hs)
RefSeq Nucleotide NM_001024401 (Hs), NM_145587 (Mm), NM_147135 (Rn)
RefSeq Protein NP_001019572 (Hs), NP_663562 (Mm), NP_671476 (Rn)
UniProtKB Q52WX2 (Hs), Q8QZX0 (Mm), Q9Z335 (Rn)
Wikipedia SBK1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: SBK1
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.5 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.7 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.0 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.7 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
gefitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF1 family: SH3 domain binding kinase 1. Last modified on 21/03/2013. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2193.