Top ▲

cyclin-dependent kinase like 3

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1984

Nomenclature: cyclin-dependent kinase like 3

Abbreviated Name: CdkL3

Family: Cyclin-dependent kinase-like (CDKL) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 592 5q31.1 CDKL3 cyclin dependent kinase like 3
Mouse - 595 11 B1.3 Cdkl3 cyclin dependent kinase like 3
Rat - 593 10q22 Cdkl3 cyclin-dependent kinase-like 3
Previous and Unofficial Names Click here for help
NKIAMRE | serine/threonine kinase NKIATRE | serine/threonine kinase NKIATRE beta
Database Links Click here for help
Alphafold Q8IVW4 (Hs), Q8BLF2 (Mm), Q9JM01 (Rn)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL1163117 (Hs)
Ensembl Gene ENSG00000006837 (Hs), ENSMUSG00000020389 (Mm), ENSRNOG00000059485 (Rn)
Entrez Gene 51265 (Hs), 213084 (Mm), 60396 (Rn)
Human Protein Atlas ENSG00000006837 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:51265 (Hs), mmu:213084 (Mm), rno:60396 (Rn)
OMIM 608459 (Hs)
Pharos Q8IVW4 (Hs)
RefSeq Nucleotide NM_001113575 (Hs), NM_001166653 (Mm), NM_021772 (Rn)
RefSeq Protein NP_001107047 (Hs), NP_001160125 (Mm), NP_068540 (Rn)
UniProtKB Q8IVW4 (Hs), Q8BLF2 (Mm), Q9JM01 (Rn)
Wikipedia CDKL3 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: CDKL3
Ligand Sp. Type Action Value Parameter
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
sorafenib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.0 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

Show »

1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Cyclin-dependent kinase-like (CDKL) family: cyclin-dependent kinase like 3. Last modified on 29/01/2016. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1984.