KCTD12

Target id: 1918

Nomenclature: KCTD12

Quaternary Structure: Complexes
GABA_B receptor

Gene and Protein Information

Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	References
Human	-	325	13q21	KCTD12	potassium channel tetramerization domain containing 12	1
Mouse	-	327	14 E2	Kctd12	potassium channel tetramerisation domain containing 12	1
Rat	-	-	15q22	Kctd12	potassium channel tetramerization domain containing 12	1

Previous and Unofficial Names
PFET1

Previous and Unofficial Names

PFET1

Database Links
Alphafold	Q96CX2 (Hs), Q6WVG3 (Mm)
ChEMBL Target	CHEMBL4523424 (Hs), CHEMBL4523353 (Mm)
Ensembl Gene	ENSG00000178695 (Hs), ENSMUSG00000098557 (Mm), ENSRNOG00000066973 (Rn)
Entrez Gene	115207 (Hs), 239217 (Mm), 364458 (Rn)
Human Protein Atlas	ENSG00000178695 (Hs)
KEGG Gene	hsa:115207 (Hs), mmu:239217 (Mm), rno:364458 (Rn)
OMIM	610521 (Hs)
Pharos	Q96CX2 (Hs)
RefSeq Nucleotide	NM_138444 (Hs), NM_177715 (Mm)
RefSeq Protein	NP_612453 (Hs), NP_808383 (Mm)
UniProtKB	Q96CX2 (Hs), Q6WVG3 (Mm)
Wikipedia	KCTD12 (Hs)

Protein Comments
KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

Protein Comments

KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

References

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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J Biol Chem, 287 (47): 39869-77. [PMID:23035119]