Target has curated data in GtoImmuPdb
Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 1065 | 16p13.3 | NLRC3 | NLR family CARD domain containing 3 | |
| Mouse | - | 1064 | 16 A1 | Nlrc3 | NLR family, CARD domain containing 3 | |
| Rat | - | - | 10 q12 | Nlrc3 | NLR family, CARD domain containing 3 | |
| Previous and Unofficial Names |
| CLR16.2 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 | NLR family, CARD domain containing 3 | Caterpiller 16.2 | NOD3 | NLR family |
| Database Links |
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| Alphafold | Q7RTR2 (Hs), Q5DU56 (Mm) |
| Ensembl Gene | ENSG00000167984 (Hs), ENSMUSG00000049871 (Mm), ENSRNOG00000024210 (Rn) |
| Entrez Gene | 197358 (Hs), 268857 (Mm), 287070 (Rn) |
| Human Protein Atlas | ENSG00000167984 (Hs) |
| KEGG Gene | hsa:197358 (Hs), mmu:268857 (Mm), rno:287070 (Rn) |
| Pharos | Q7RTR2 (Hs) |
| UniProtKB | Q7RTR2 (Hs), Q5DU56 (Mm) |
| Wikipedia | NLRC3 (Hs) |
| Immunopharmacology Comments |
| NLRC3 is an intracellular pattern recognition receptor of the innate immune system. It has been shown to directly interact with and inhibit the type I interferon response of the intracellular DNA sensor STING to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses [1-2]. |
| Immuno Process Associations | ||
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| Physiological Functions Comments | |
| Negative regulation of inflammatory signalling. |
References
1. Mangan MS, Latz E. (2014) NLRC3 puts the brakes on STING. Immunity, 40 (3): 305-6. [PMID:24656040]
2. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA et al.. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity, 40 (3): 329-41. [PMID:24560620]
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