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PLCγ2

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1408

Nomenclature: PLCγ2

Family: Phosphoinositide-specific phospholipase C

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1265 16q24.1 PLCG2 phospholipase C gamma 2
Mouse - 1265 8 64.26 cM Plcg2 phospholipase C, gamma 2
Rat - 1265 19q12 Plcg2 phospholipase C, gamma 2
Previous and Unofficial Names Click here for help
PLC-IV | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | phosphoinositide phospholipase C-gamma-2 | phospholipase C, gamma 2 | phospholipase C-IV | PLCgamma2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | phospholipase C
Database Links Click here for help
Alphafold P16885 (Hs), Q8CIH5 (Mm), P24135 (Rn)
BRENDA 3.1.4.11
CATH/Gene3D 2.60.40.150, 3.20.20.190, 2.30.29.30
ChEMBL Target CHEMBL4100 (Hs), CHEMBL3608199 (Mm), CHEMBL5230 (Rn)
Ensembl Gene ENSG00000197943 (Hs), ENSMUSG00000034330 (Mm), ENSRNOG00000051986 (Rn)
Entrez Gene 5336 (Hs), 234779 (Mm), 29337 (Rn)
Human Protein Atlas ENSG00000197943 (Hs)
KEGG Enzyme 3.1.4.11
KEGG Gene hsa:5336 (Hs), mmu:234779 (Mm), rno:29337 (Rn)
OMIM 600220 (Hs)
Pharos P16885 (Hs)
RefSeq Nucleotide NM_002661 (Hs)
RefSeq Protein NP_002652 (Hs)
UniProtKB P16885 (Hs), Q8CIH5 (Mm), P24135 (Rn)
Wikipedia PLCG2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3, Rac1 (RAC1, P63000), Rac2 (RAC2, P15153), Rac3 (RAC3, P60763)  [1,3,7]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CCT129957 Small molecule or natural product Hs Inhibition 5.5 pIC50 4
⤷ pIC50 5.5 (IC50 3x10-6 M) [4]
Description: Average IC50 (n=3)
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,5], although PLCγ1 may be the predominant isoform active in human mast cells [6].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cellular signalling
Immuno Process:  Cytokine production & signalling

References

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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]

3. Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. (2005) Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem, 280 (47): 38923-31. [PMID:16172125]

4. Reynisson J, Court W, O'Neill C, Day J, Patterson L, McDonald E, Workman P, Katan M, Eccles SA. (2009) The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem, 17 (8): 3169-76. [PMID:19303309]

5. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

6. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]

7. Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P et al.. (2008) rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem, 283 (44): 30351-62. [PMID:18728011]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ2. Last modified on 14/02/2017. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1408.