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GPR142

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Target not currently curated in GtoImmuPdb

Target id: 132

Nomenclature: GPR142

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 462 17q25.1 GPR142 G protein-coupled receptor 142 1-2
Mouse 7 365 11 E2 Gpr142 G protein-coupled receptor 142 1-2
Rat 7 340 10q32.1 Gpr142 G protein-coupled receptor 142
Previous and Unofficial Names Click here for help
KIF19 | AXOR103 | G-protein coupled receptor PGR2
Database Links Click here for help
Specialist databases
GPCRdb gp142_human (Hs), gp142_mouse (Mm)
Other databases
Alphafold Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
ChEMBL Target CHEMBL2069161 (Hs), CHEMBL2069162 (Mm), CHEMBL3632456 (Rn)
Ensembl Gene ENSG00000257008 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
Entrez Gene 350383 (Hs), 217302 (Mm), 501735 (Rn)
Human Protein Atlas ENSG00000257008 (Hs)
KEGG Gene hsa:350383 (Hs), mmu:217302 (Mm), rno:501735 (Rn)
OMIM 609046 (Hs)
Pharos Q7Z601 (Hs)
RefSeq Nucleotide NM_181790 (Hs), NM_181749 (Mm)
RefSeq Protein NP_861455 (Hs), NP_861414 (Mm)
UniProtKB Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
Wikipedia GPR142 (Hs)

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 33 [Toda et al., 2013] Small molecule or natural product Hs Agonist 7.7 pEC50 3
⤷ pEC50 7.7 (EC50 2.2x10-8 M) [3]
Agonist Comments
The high identity of 50% between GPR142 and GPR139 is suggestive of shared ligands [2].
Tissue Distribution Click here for help
Spleen, liver, kidney, testis, brain
Species:  Mouse
Technique:  Multi-tissue cDNA panel (PCR)
References:  2
Brain (intense labeling of hippocampus, dentate gyrus, cerebral cortex, medial thalamic nuclei, anterior hypothalamic nuclei), thymus, liver, cartilage
Species:  Mouse
Technique:  In situ hybridization
References:  2
Tissue Distribution Comments
Embryonic expression of GPR142 suggests the receptor may play a role in brain, bone and blood formation [2].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R86H
Global MAF (%):  1
Subpopulation MAF (%):  ASN: 3
Minor allele count:  A=0.007/16
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs76896732
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  H132D
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 12|3
Minor allele count:  C=0.032/70
SNP accession:  rs2382647
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R124Q
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 3
Minor allele count:  A=0.006/14
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs73997706
Validation:  1000 Genomes, Frequency

References

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1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett, 554 (3): 381-8. [PMID:14623098]

2. Süsens U, Hermans-Borgmeyer I, Urny J, Schaller HC. (2006) Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Neuropharmacology, 50 (4): 512-20. [PMID:16378626]

3. Toda N, Hao X, Ogawa Y, Oda K, Yu M, Fu Z, Chen Y, Kim Y, Lizarzaburu M, Lively S et al.. (2013) Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes. ACS Med Chem Lett, 4 (8): 790-4. [PMID:24900747]

Contributors

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