Nuclear Hormone Receptor List | IUPHAR/BPS Guide to PHARMACOLOGY

Nuclear hormone receptors

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0B. DAX-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
0B. DAX-like receptors		NR0B1	DAX1	NR0B1	Nr0b1	Nr0b1	Orphan
0B. DAX-like receptors		NR0B2	SHP	NR0B2	Nr0b2	Nr0b2	Orphan
1A. Thyroid hormone receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1A. Thyroid hormone receptors	T₄ triiodothyronine	NR1A1	Thyroid hormone receptor-α	THRA	Thra	Thra	Triiodothyronine is the more potent endogenous ligand
1A. Thyroid hormone receptors	T₄ triiodothyronine	NR1A2	Thyroid hormone receptor-β	THRB	Thrb	Thrb	Triiodothyronine is the more potent endogenous ligand
1B. Retinoic acid receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1B. Retinoic acid receptors	tretinoin	NR1B1	Retinoic acid receptor-α	RARA	Rara	Rara
1B. Retinoic acid receptors	tretinoin	NR1B2	Retinoic acid receptor-β	RARB	Rarb	Rarb
1B. Retinoic acid receptors	tretinoin	NR1B3	Retinoic acid receptor-γ	RARG	Rarg	Rarg
1C. Peroxisome proliferator-activated receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1C. Peroxisome proliferator-activated receptors	LTB₄ pristanic acid 8S-HETE	NR1C1	Peroxisome proliferator-activated receptor-α	PPARA	Ppara	Ppara	LTB₄, fatty acids and eisosanoids are natural ligands
1C. Peroxisome proliferator-activated receptors	tretinoin	NR1C2	Peroxisome proliferator-activated receptor-β/δ	PPARD	Ppard	Ppard	Fatty acids and eisosanoids are natural ligands
1C. Peroxisome proliferator-activated receptors	15-deoxy-Δ-12,14-prostaglandin J2 linoleic acid	NR1C3	Peroxisome proliferator-activated receptor-γ	PPARG	Pparg	Pparg	Fatty acids, prostaglandin J2 and eisosanoids are reported natural ligands
1D. Rev-Erb receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1D. Rev-Erb receptors	heme	NR1D1	Rev-Erb-α	NR1D1	Nr1d1	Nr1d1	Orphan
1D. Rev-Erb receptors	heme	NR1D2	Rev-Erb-β	NR1D2	Nr1d2	Nr1d2	Orphan
1F. Retinoic acid-related orphans
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1F. Retinoic acid-related orphans	cholesterol	NR1F1	RAR-related orphan receptor-α	RORA	Rora	Rora
1F. Retinoic acid-related orphans	tretinoin	NR1F2	RAR-related orphan receptor-β	RORB	Rorb	Rorb
1F. Retinoic acid-related orphans	25-hydroxycholesterol	NR1F3	RAR-related orphan receptor-γ	RORC	Rorc	Rorc	Orphan
1H. Liver X receptor-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1H. Liver X receptor-like receptors	chenodeoxycholic acid cholic acid deoxycholic acid lithocholic acid 22R-hydroxycholesterol	NR1H4	Farnesoid X receptor	NR1H4	Nr1h4	Nr1h4	A series of bile acids are natural ligands
1H. Liver X receptor-like receptors	cholesten desmosterol lanosterol vitamin D3	NR1H5	Farnesoid X receptor-β	NR1H5P	Nr1h5	Nr1h5	A series of oxysterols and bile acids are natural ligands
1H. Liver X receptor-like receptors	24(S), 25-epoxycholesterol 24(S)-hydroxycholesterol 27-hydroxycholesterol 22R-hydroxycholesterol	NR1H3	Liver X receptor-α	NR1H3	Nr1h3	Nr1h3	A series of oxysterols are natural ligands
1H. Liver X receptor-like receptors	24(S), 25-epoxycholesterol 24(S)-hydroxycholesterol 27-hydroxycholesterol 22R-hydroxycholesterol	NR1H2	Liver X receptor-β	NR1H2	Nr1h2	Nr1h2	A series of oxysterols are natural ligands
1I. Vitamin D receptor-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
1I. Vitamin D receptor-like receptors	calcitriol-26,23-lactone 1,25-dihydroxyvitamin D3 3-keto-lithocholic acid lithocholic acid	NR1I1	Vitamin D receptor	VDR	Vdr	Vdr
1I. Vitamin D receptor-like receptors	17β-estradiol 3-keto-lithocholic acid lithocholic acid	NR1I2	Pregnane X receptor	NR1I2	Nr1i2	Nr1i2	Xenobiotics, steroids and benzoates have been proposed as the natural ligands
1I. Vitamin D receptor-like receptors		NR1I3	Constitutive androstane receptor	NR1I3	Nr1i3	Nr1i3	Xenobiotics and androstanes have been proposed as the natural ligands
2A. Hepatocyte nuclear factor-4 receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
2A. Hepatocyte nuclear factor-4 receptors	linoleic acid	NR2A1	Hepatocyte nuclear factor-4-α	HNF4A	Hnf4a	Hnf4a	Orphan
2A. Hepatocyte nuclear factor-4 receptors		NR2A2	Hepatocyte nuclear factor-4-γ	HNF4G	Hnf4g	Hnf4g	Orphan
2B. Retinoid X receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
2B. Retinoid X receptors	alitretinoin docosahexaenoic acid	NR2B1	Retinoid X receptor-α	RXRA	Rxra	Rxra
2B. Retinoid X receptors	alitretinoin	NR2B2	Retinoid X receptor-β	RXRB	Rxrb	Rxrb
2B. Retinoid X receptors	alitretinoin	NR2B3	Retinoid X receptor-γ	RXRG	Rxrg	Rxrg
2C. Testicular receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
2C. Testicular receptors		NR2C1	Testicular receptor 2	NR2C1	Nr2c1	Nr2c1	Orphan
2C. Testicular receptors	retinol tretinoin	NR2C2	Testicular receptor 4	NR2C2	Nr2c2	Nr2c2	Orphan
2E. Tailless-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
2E. Tailless-like receptors		NR2E1	TLX	NR2E1	Nr2e1	Nr2e1	Orphan
2E. Tailless-like receptors		NR2E3	PNR	NR2E3		Nr2e3	Orphan
2F. COUP-TF-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
2F. COUP-TF-like receptors		NR2F1	COUP-TF1	NR2F1	Nr2f1	Nr2f1	Orphan
2F. COUP-TF-like receptors		NR2F2	COUP-TF2	NR2F2	Nr2f2	Nr2f2	Orphan
2F. COUP-TF-like receptors		NR2F6	V-erbA-related gene	NR2F6	Nr2f6	Nr2f6	Orphan
3A. Estrogen receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
3A. Estrogen receptors	17β-estradiol estriol estrone	NR3A1	Estrogen receptor-α	ESR1	Esr1	Esr1
3A. Estrogen receptors	17β-estradiol estrone	NR3A2	Estrogen receptor-β	ESR2	Esr2	Esr2
3B. Estrogen-related receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
3B. Estrogen-related receptors		NR3B1	Estrogen-related receptor-α	ESRRA	Esrra	Esrra	Orphan
3B. Estrogen-related receptors		NR3B2	Estrogen-related receptor-β	ESRRB	Esrrb	Esrrb	Orphan
3B. Estrogen-related receptors		NR3B3	Estrogen-related receptor-γ	ESRRG	Esrrg	Esrrg	Orphan
3C. 3-Ketosteroid receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
3C. 3-Ketosteroid receptors	dihydrotestosterone testosterone	NR3C4	Androgen receptor	AR	Ar	Ar	Dihydrotestosterone has greater potency than testosterone
3C. 3-Ketosteroid receptors	aldosterone corticosterone cortisol deoxycorticosterone deoxycortisone	NR3C1	Glucocorticoid receptor	NR3C1	Nr3c1	Nr3c1	Cortisol and corticosterone are the principal endogenous agonists
3C. 3-Ketosteroid receptors	aldosterone corticosterone cortisol deoxycorticosterone progesterone	NR3C2	Mineralocorticoid receptor	NR3C2	Nr3c2	Nr3c2
3C. 3-Ketosteroid receptors	progesterone	NR3C3	Progesterone receptor	PGR	Pgr	Pgr
4A. Nerve growth factor IB-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
4A. Nerve growth factor IB-like receptors		NR4A1	Nerve Growth factor IB	NR4A1	Nr4a1	Nr4a1	Orphan
4A. Nerve growth factor IB-like receptors		NR4A2	Nuclear receptor related 1	NR4A2	Nr4a2	Nr4a2	Orphan
4A. Nerve growth factor IB-like receptors		NR4A3	Neuron-derived orphan receptor 1	NR4A3	Nr4a3	Nr4a3	Orphan
5A. Fushi tarazu F1-like receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
5A. Fushi tarazu F1-like receptors		NR5A1	Steroidogenic factor 1	NR5A1	Nr5a1	Nr5a1	Orphan
5A. Fushi tarazu F1-like receptors		NR5A2	Liver receptor homolog-1	NR5A2	Nr5a2	Nr5a2	Orphan
6A. Germ cell nuclear factor receptors
Family name	Ligand	Receptor nomenclature	Receptor common name	Human gene symbol	Rat gene symbol	Mouse gene symbol	Comment
6A. Germ cell nuclear factor receptors		NR6A1	Germ cell nuclear factor	NR6A1	Nr6a1	Nr6a1	Orphan