The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

GtoImmuPdb ligands only: Low molecular weight, non-polymeric compounds produced via either total synthesis or semi-synthetic processes.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z 

Ligand name ID Synonyms
A Back to top
852A 9025
A286982 6592 A 286982, A-286982
A438079 4118 A 438079, A-438079
abediterol 9326 LAS-100977
ABT-737 8320 ABT 737, ABT737, compound 2 [PMID 17256834]
AC430 9177 AC-430
acalabrutinib 8912 ACP-196, Example 6 [US20140155385 A1]
ACT-389949 9511
acumapimod 9203 BCT 197, BCT-197, BCT197, compound A [WO2013139809]
AH6809 1896 AH 6809, AH-6809
alcaftadine 7587 Lastacaft®, R-89674
alimemazine 7237 Nedeltran®, trimeprazine
alpelisib 7955 BYL 719, BYL-719, NVP-BYL719
3 alpha-aminocholestane 9564 3AC, 3 α-aminocholestane
alvelestat 6476 AZD 9668, AZD-9668, AZD9668, KB-105160
ALX-101 9625 A-110, example 36 [WO2013130892], rovazolac (proposed INN)
amcinonide 7060 CL-34699, Cyclocort®
amelubant 8463 BIIL 284, BIIL-284
AMG319 8917 AMG 319, AMG-319
amiselimod 9319 Example 1 [US20090137530], MT-1303, MT1303
amiselimod phosphate 9491 amiselimod-P
amlexanox 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
ancriviroc 804 SCH 351125, SCH-351125, SCH-C
apafant 1860 WEB 2086 BS, WEB-2086
apremilast 7372 CC-10004, Otezla®
arformoterol 7479 Brovana®, YM-08316
(R)-ARN2508 9000 compound (-)-10r [PMID: 26774927], example 19 [WO2014023643]
(S)-ARN2508 8999 compound (+)-10r [PMID: 26774927], example 20 [WO2014023643]
ARRY-382 9108 ARRY 382, ARRY382
AS101 437 AS 101, AS-101
asimadoline 9279 EMD 61 753, EMD 61753, EMD-61753
ASP4058 9569 ASP-4058
aspirin 4139 Acetophen®, acetylsalicylic acid, Aspirin®
AT38 9020 [3-(aminocarbonyl)furoxan-4-yl]methyl salicylate
ATB-346 9534 ATB 346
atracurium 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
auranofin 6306 Ridaura®, SK&F-39162, SK-39162
avacopan 9450 CCX-168, CCX168
AZ13102909 9577 AZ909
AZ3451 9560
AZ7188 9586
AZ8838 9585
azacitidine 6796 5-AZAC, 5-azacytidine, ladakamycin, U-18496, Vidaza®
azatadine 7119 Optimine®, SCH-10649
azathioprine 7120 Azasan®, BW-57-322, Imuran®
AZD1236 7844 AZD 1236, AZD-1236
AZD1981 7680 AZD 1981, AZD-1981
AZD2423 7825 AZD 2423, AZD-2423
AZD5069 8948
AZD5672 7686 AZD 5672, AZD-5672
AZD6605 7823 AZ 11920155, AZ-11920155, AZ11920155, AZD 6605, AZD-6605
AZD6703 7687 AZ 12012199, AZ-12012199, AZ12012199, AZD 6703, AZD-6703
AZD7594 9325 AZ13189620
AZD7986 9412 compound 30
AZD8848 9256 DSP-3025
AZD9056 7826 AZD 9056, AZD-9056
azelaic acid 7484 Azelex®, Finacea®, ZK-62498
AZ11657312 (salt free) 7722
 
B Back to top
bafetinib 7906 INNO-406, Lyn-IN-1, NS-187
baricitinib 7792 INCB-028050, LY-3009104, LY3009104, Olumiant®
BAYu9773 3381 BAY u9773, BAY-u 9773
beclometasone 7059 beclomethasone, SCH-18020W
beclometasone dipropionate 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
belnacasan 9035 VX-765
3beta-Hydroxy-20(29)-lupene 9028 Fagarasterol, Lupeol
BGB-3111 9591
BI605906 9357 3-Amino-4-(1,1-difluoro- propyl)-6-(4-methanesulfonyl- piperidin-1-yl)-thieno[2,3- b]pyridine-2-carboxylic acid amide, compound 115 [US20070293533]
BIIB021 9258
bimosiamose 9049 compound 15e [PMID: 9544210], TBC 1269, TBC-1269, TBC1269
BIX02189 9380 BIX 02189, BIX-02189
BLZ945 8250 BLZ 945, BLZ-945
BMS-1166 9608 compound 2c [PMID: 28613862]
BMS-202 9607 compound 1c [PMID: 28613862], PD1-PDL1 inhibitor 2
BMS-345541 5669 BMS 345541, BMS345541
BMS-561392 6509 BMS 561392, BMS561392, DPC-333
BMS-582949 7838 BMS 582949, BMS582949, PS 540446, PS-540446, PS540446
BMS-681 9430 compound 13d [PMID: 25893046]
BMS-817399 9497 compound 29 [PMID: 25101488]
bosutinib 5710 Bosulif®, SK 606, SK-606, SKI 606
BRL-15572 10 BRL 15572, BRL-15,572, BRL15572
bromfenac 7131 AHR-10282B, Bromday®, Prolensa®, Xibrom®
BTP2 2438 YM-58483
BX 471 767 BX-471, BX-741
BX-795 8006 BX 795, BX795
 
C Back to top
C108297 9180 Compound 52 [PMID:18226897]
C391 9570 compound 5 [PMID: 27994760]
carbenoxolone 4151
carprofen 7141 Ro-205720000
CBS-3595 9610
CC-220 9618 compound 6 [PMID: 28425720], iberdomide (proposed INN)
CC-885 9224
CCR2-RA-[R] 9431 analog 49 (Dasse et al., 2007)
CDP840 9330 CDP 840, CDP-840
celecoxib 2892 Celecox®, Onsenal®
cerdulatinib 8957 PRT 062070, PRT-062070, PRT-2070, PRT062070
cetirizine 1222 Reactine®, Zyrtec®
CGI1746 8066 CGI 1746, CGI-1746
CGI560 9264 CGI-560
CHMFL-BTK-11 9516
cicaprost 1917 ZK 96480, ZK-96480
ciclesonide 7469 Alvesco®, Omnaris®, RPR-251526
cilomilast 7407 SB-207499
cipemastat 6466 Ro 28-2653
clemastine 6063 HS-592, meclastin, Tavegil®, Tavist®
clobenpropit 1223 VUF 9153, VUF-9153
clobetasone 9088 Eumovate®
clodronic acid 9605 Bonefos®, Clasteon ®, clodronate, Loron®
clofazimine 9184 Lamprene®
clopidogrel (active metabolite) 1772
CNX-774 9266
compound 48/80 5531
compound 17d [PMID: 23099093] 8196
compound 4g [PMID: 22220592] 9236 Example XCII [US20160175314]
compound 4g [PMID: 2680437] 9198
compound 8ic [PMID: 19081254] 9478 CCR4 Antagonist
compound II [PMID: 21329883] 9579
compound 5i [PMID: 24099220] 8223 GNF-PF-3777
compound 12 [PMID: 27448772] 9453
compound 15 [PMID: 25411721] 9078 example 252 [WO2007110237]
compound 16 [PMID: 26794040] 9223
compound 1 [PMID: 24930776] 9092 DB36
compound 21 [PMID: 22802221] 6918 C21
compound 21 [PMID: 24900635] 8187
compound 24 [PMID: 26987013 ] 9252
compound 36 [PMID: 21958547] 9391
compound 3 [PMID: 14640538] 8675 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, 2-Mmgetpa, DL-2-mercaptomethyl-3-guanidinoethyl-thiopropanoic acid, mergepta, MGTA
compound 3 [PMID: 28603634] 9628
compound 41 [PMID: 25000588] 9349
compound 43 [PMID: 26751273] 9492
compound 47 [PMID: 28737909] 9646
compound 6 [PMID: 25874594] 9178
compound 76 [PMID: 28657314] 9609
compound 1 [WO2012007375] 8084
compound 7 [WO2012007375] 8085
18c [PMID: 25901531] 9227
crenolanib 7882 ARO-002, CP 868596, CP-868596
crisaborole 9151 AN 2728, AN2728, compound 5b [PMID: 19303290], Eucrisa®
cromoglicic acid 7608 cromoglycate, cromolyn, cromolyn sodium, FPL-670, Intal®, Opticrom®, sodium cromoglicate
CUDC-907 8952 CUDC 907, PI3K/HDAC Inhibitor centn
 
D Back to top
D4476 5940 casein kinase I inhibitor, CK1 inhibitor, D 4476
dagrocorat 9650 PF-00251802
danirixin 8500 GSK-1325756B, GSK1325756, GSK1325756B
dasatinib 5678 BMS 345825, BMS 354825, BMS 35482513, Sprycel®
decernotinib 8309 adelatinib, VRT-831509, VX-509
deflazacort 9477 Emflaza®, MDL 458
desloratadine 7157 Clarinex®, SCH-34117
dexamethasone 2768 Decadron®, desametasone, fluormethylprednisolone
diamorphine 9082 acetomorphine, diacetylmorphine, heroin
diclofenac 2714 Cataflam®, CGP-45840B, GP-45840, Voltaren®, Voltarol®
diflunisal 7162 Dolobid®
dilmapimod 7815 SB-681323
dinaciclib 7379 SCH727965
diphenylpyraline 7165 Hispril®
DMAT 9323 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, CK2 Inhibitor II
doramapimod 5668 BIRB 796BS, BIRB-796, BIRB796
duvelisib 7795 compound 4904 [Patent US8193182], INK-1197, IPI-145
 
E Back to top
E6201 7836 E 6201, E-6201
elubirixin 8499 SB 656933, SB-656933, SB656933
entospletinib 7889 GS-9973
EP4A 1952 EP4A, L-161982, L161982
epacadostat 8221 IDO inhibitor 1, INCB 24360, INCB-24360, INCB024360
ER-27319 9611
ERK inhibitor II 5966 FR-180204, FR180204
esflurbiprofen 9420 (S)-flurbiprofen, BTS-24332, SFPP, TT-063
etodolac 7185 AY-24236, Lodine®
etoricoxib 2896 Arcoxia®, MK 0663, MK-0663
etrasimod 9331 APD-334, APD334, APD334-003, compound 4 [PMID: 25516790]
example 131 [WO2009133348] 8489
example 36 [WO2016177845] 9555
 
F Back to top
F16357 9255 Compound 39 [PMID: 19791800], Example 1 in WO2007147824
fenoprofen 4820 fenoprofen calcium, Nalfon®
fevipiprant 8995 NVP-QAW039, QAW039
fexofenadine 4819 Allegra®, fexofenadine HCl
filgotinib 7913 GLPG-0634, GLPG0634
fingolimod 2407 FTY-720, FTY720, Gilenya®
FIPI 8781 compound 14 [PMID: 19136975]
fludroxycortide 7606 Cordran®, flurandrenolide, flurandrenolone, Haelan®
flufenamic acid 2447
flurbiprofen 4194 Ansaid®, Froben®
fluticasone 6699 Advair®, Flovent HFA®, Veramyst®
formoterol 3465 BD-40A, CGP-25827A, Foradil®, Oxeze/Oxis®, YM-08316
fosdagrocorat 9649 PF-04171327
fostamatinib 7796 R 788, R-788, R7935788
FR122047 5191 FR 122047, FR 122047 hydrochloride, FR-122047
 
G Back to top
gabapentin 5483 CI 945, Go 3450, GOE 2450, GOE 3450, Neurontin®
gandotinib 7909 LY-2784544, LY2784544
GB88 6658 GB 88, GB-88
GDC-0834 9263 GDC 0834
GlcC14C18 9483 6-O-(2'(R,S)-tetradecyloctadecanoyl)-D-glucose
GLPG0974 8417 compound 99 [PMID 25380412]
GLPG1690 9561 compound 11 [PMID: 28414242], GLPG-1690
glycopyrrolate 7459 AHR-504, Robinul®, Seebri Neohaler®
GNF362 9548 example 71 [US20090306039]
GSK143 9388 compound 20 [PMID: 21903390]
GSK2245035 9254 compound 32 [PMID: 26861551]
GSK2879552 9116 Example 26 [WO2012135113], GSK-2879552
GSK2982772 9554 compound 5 [PMID: 28151659]
GSK583 9134 GSK'583
GSK866 9653
GSK-J1 7027
GSK-J4 8979 GSK J4, GSKJ4
G1T28 9626 trilaciclib (proposed INN)
GW3965 2754 C473027, GW 3965, GW-3965
GW5074 8072 GW-5074, Raf1 kinase inhibitor I
GW 627368 1953 GW-627368, GW627368, saccharic acid
 
H Back to top
HG-9-91-01 8049 HY-15776
HTMT 1273 histamine-trifluoromethyl-toluidine, histamine-trifluoromethyltoluide, HTFMT
hydroxyzine 7199 Atarax®, hydroxyzine hydrochloride, hydroxyzine pamoate, Vistaril®
 
I Back to top
I-BET-762 7033 CS-0717, GSK 525762A, GSK525762, I-BET762, molibresib (proposed INN)
ibrutinib 6912 Imbruvica®, PCI-32765
ibuprofen 2713 Advil®, Brufen®, ibuprofen lysine, ibuprofen sodium, Motrin®, Nurofen®, U-18573
IC-87114 9376 IC87114
idelalisib 6741 CAL-101/CAL101, GS-1101, Zydelig®
IKK-2 inhibitor IV 5986 TPCA-1, TPCA1
iloprost 1895 Ventavis®
imatinib 5687 CGP 57148, Gleevec®, Glivec®, STI571
imetit 1250
imiquimod 5003 Aldara®, R837, S-26308, Zyclara®
immepip 1251
INCB3284 9045 compound 13 [PMID: 24900329], INCB 3284
INCB8761 9032 compound 17 [PMID: 24900280], INCB-8761, PF-4136309, PF4136309
indacaterol 7455 Arcapta Neohaler®, Onbrez®, QAB-149, QAB149
indomethacin 1909 Indocid®, Indocin®
IPI549 9563 compound 26 [PMID: 27660692], IPI-549
ipratropium 325 Atrovent®, Ipraxa®
IRAK-1/4 inhibitor 5990
IRAK4 inhibitor 4b [PMID: 18474425] 8080
IRAK4 inhibitor rac-45 [PMID: 18501603] 8081
isoetarine 7205 Bronkometer®, Bronkosol®, WIN-3406
isothiourea-1t 2899 IT1t
itacitinib 8364 Examlpe 294 [WO2011112662], INCB-039110
 
J Back to top
JNJ-10191584 1277 compound 12, JNJ 10191584, VUF 6002, VUF6002
JNJ-10311795 6563
JNJ-39758979 8984 JNJ 39758979, JNJ39758979
JNJ-40346527 8942 US8497376, 15
JNK inhibitor IX 5996 AC1LG8KT, BAS 01816608, TCS JNK 5a
JTE-052 9619 delgocitinib (proposed INN)
 
K Back to top
KD025 9558 KD-025, SLx 2119, SLx2119
ketoprofen 4795 Actron®, Orudis®
ketorolac 6661 Acular®, Toradol®
 
L Back to top
L-798,106 1941 L-798106, L798106
leflunomide 6825 Arabloc®, Arava®, HWA 486, HWA-486, lefunamide, SU-101
lenalidomide 7331 CC-5013, CDC-501, Revlimid®
leniolisib 9424 CDZ-173, CDZ173, Example 67 [WO2012004299]
lestaurtinib 5672 CEP-701, KT-5555, SP924
LFM-A13 9262 α-cyano-beta-hydroxy-β-methyl-N-(2, 5-dibromophenyl)propenamide, alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide
L6H21 9027
LHVS 9298 morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl, morpholinurea-leucine-homophenylalaninevinyl phenyl sulfone
lifitegrast 7533 compound 1g [PMID: 24900456], SAR 1118, SAR-1118, SAR-1118-023, Xiidra®
lisofylline 9225 (R)-lisophylline, CT-1501R
LM10 9016 LM-10
loratadine 7216 Claritin®, SCH-29851
losmapimod 7835 GS856553, GW856553
lumiracoxib 2897 Prexige®
LY255283 3351 CGS 23356, LY 255283, LY-255283
 
M Back to top
3M-002 9270 CL-075, CL075
mapracorat 9654 BOL-303242-X, ZK-245186, ZK245186
maraviroc 806 Celsentri®, Selzentry®, UK 427857, UK-427,857
masitinib 5656 AB-1010, AB1010, Masican® (proposed trade name)
meclofenamic acid 7219 CL-583, INF-4668, Meclomen®
mefenamic acid 2593 CI-473, CN-35355, INF-3355, Ponstan®, Ponstel®
meloxicam 7220 Mobic®, UHAC-62XX
methacholine 7438 methacholine bromide, Provocholine®
methimazole 6649 Tapazole®, Thiamazole®
methotrexate 4815 Abitrexate®, amethopterin, Rasuvo®
(R)-α-methylhistamine 1236 (R)-α-MeHA, alpha-methylhistamine
midostaurin 5702 CGP 41231, CGP 41251, N-benzoylstaurosporine, PKC412, Rydapt®
mifepristone 2805 Mifeprex®, RU-486, RU486
MK-0812 9048 MK0812
MK-886 2655 L 663536, MK886
ML324 9584 ML-324
MLN-120B 5694 ML120B, MLN120B
mometasone 9029 Elocon® (topical), Nasonex®
mongersen 8277 GED-0301
montelukast 3340 Singulair®
motolimod 9026 VTX-2337
MPI-0485520