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The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

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GtoImmuPdb ligands only: Synthetic, semi-synthetic and natural peptides encoded in genomes other than human, rat and mouse (including oligopeptides and cyclic peptides).
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Ligand name ID Synonyms
A Back to top
abatacept Approved drug Immunopharmacology Ligand 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
Ac-SDKP Immunopharmacology Ligand 10060 goralatide, seraspenide
AF12198 Immunopharmacology Ligand 4861 AF 12198, AF-12198
AL-78898A Immunopharmacology Ligand 9219 4(1MeW), POT-4
alefacept Approved drug Immunopharmacology Ligand 6787 Amevive®, BG 9273, BG 9712, BG-9273, BG-9712, Lfa3Tip
AM-6120 Immunopharmacology Ligand 10119 AM6120, peptide 41 [PMID: 30346167]
AMT-101 Immunopharmacology Ligand 11645
anakinra Approved drug Immunopharmacology Ligand 6972 antril, Kineret®
atacicept Immunopharmacology Ligand 9517 TACI-Fc, TACI-Ig
azapro-3 Immunopharmacology Ligand 9221
 
B Back to top
belatacept Approved drug Immunopharmacology Ligand 6892 BMS-224818, LEA29Y, Nulojix®
bempegaldesleukin Immunopharmacology Ligand 10659 NKTR-214, NKTR214
bihelical apoA-I mimetic peptide 5A Immunopharmacology Ligand 9183 5A peptide
blisibimod Immunopharmacology Ligand 9518 A-623, AGP3 peptibody, AMG 623, Fc-Agp-3
brimapitide Immunopharmacology Ligand 9101 AM-111, D-JNKI-1, XG-102
BT7480 Immunopharmacology Ligand 12060 BCY11863, BT-7480
 
C Back to top
cetrorelix Approved drug Immunopharmacology Ligand 1190 Cetrotide®, SB-075
cibinetide Immunopharmacology Ligand 9677 ARA 290, ARA-290, PH-BSP, PHBSP
compound 3c [PMID: 30360354] Immunopharmacology Ligand 10591 [As(4-F)F4]-GHRP-6, azasulfuryl-p-fluorophenylalanine-4-[As(4-F)F4]-GHRP-6, H-His-D-Trp-Ala-(4-F)AsF-D-Phe-Lys-NH2
compstatin Immunopharmacology Ligand 9218
corticotropin zinc hydroxide Approved drug Immunopharmacology Ligand 6967
cyclosporin A Approved drug Immunopharmacology Ligand 1024 ciclosporin, cyclosporine, cyclosporine A, Ikervis® (opthalmic solution), Neoral®, Sandimmun®, Verkazia® (opthalmic solution)
 
D Back to top
denileukin diftitox Approved drug Immunopharmacology Ligand 7044 DAB389 IL2, LY 335348, Ontak®
difelikefalin Approved drug Immunopharmacology Ligand 9044 CR845, D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid], FE-202845, Kapruvia®, Korsuva®, SEQ ID NO: 2
 
E Back to top
ecallantide Approved drug Immunopharmacology Ligand 6955 DX-88, FOV2302, Kalbitor®
efineptakin alfa Immunopharmacology Ligand 11097 GX-I7, Hyleukin-7, Il-7 hybrid Fc, NT-I7, rhIL-7-hyFc, TJ-107
efzofitimod Immunopharmacology Ligand 13199 ATYR-1923, ATYR1923, KRP-R120
etanercept Approved drug Immunopharmacology Ligand 6789 Enbrel®, Rhu Tnfr:Fc, TNFR-Fc, TNR 001
 
F Back to top
filgrastim Approved drug Immunopharmacology Ligand 6968 Filcad®, Imumax ®, R-METHUG-CSF
 
G Back to top
GLP-2 analogue 10 Immunopharmacology Ligand 9896
 
H Back to top
HpARI Immunopharmacology Ligand 9685 H. polygyrus Alarmin Release Inhibitor
H. polygyrus TGF-β mimic Immunopharmacology Ligand 9713 Hp-TGM
HsTX1[R14A] Immunopharmacology Ligand 9582 KTx 6.3
 
I Back to top
iberiotoxin Immunopharmacology Ligand 4218 IbTX
icatibant Approved drug Immunopharmacology Ligand 667 D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]BK, Firazyr®, HOE 140, HOE140
IFN-β1b (recombinant human) Approved drug Immunopharmacology Ligand 8340 Betaferon®, Betaseron®, Extavia®, IFNb1b
IgE heavy chain Immunopharmacology Ligand 9557
isunakinra Immunopharmacology Ligand 9704 EBI-005
 
L Back to top
Large proline-rich protein BAG6 Immunopharmacology Ligand 11143 BAG6
 
M Back to top
MK-7110 Immunopharmacology Ligand 11395 CD24-Fc, CD24Fc
MMK-1 Immunopharmacology Ligand 6240 MMK 1
motixafortide Approved drug Immunopharmacology Ligand 10679 4F-Benzoyl-TN14003, Aphexda®, BKT140, BL-8040, TF14016
 
O Back to top
olamkicept Immunopharmacology Ligand 9729 FE 999301, FE-301, FE-999301, TJ301
oprelvekin Approved drug Immunopharmacology Ligand 6971 Neumega®
 
P Back to top
Pam2CSK4 Immunopharmacology Ligand 8560
Pam3CSK4 Immunopharmacology Ligand 8558
pCXCL8-1aa Immunopharmacology Ligand 9938
peginterferon alfa-2b Approved drug Immunopharmacology Ligand 7462 PegIntron®, Sylatron®
peginterferon beta-1a Approved drug Immunopharmacology Ligand 7637 interferon beta 1-alpha, PEG-INF-β-1a, Plegridy®
peptide Cp40 [PMID: 25982307] Immunopharmacology Ligand 9220 peptide 14
peptide 30 [PMID: 27019010] Immunopharmacology Ligand 9253
PMX205 Immunopharmacology Ligand 5762 ALS-205, PMX 205, PMX-205
 
Q Back to top
QWF Immunopharmacology Ligand 9568 Boc-Gln-D-Trp(CH0)-Phe-OBzl, Nα-[Nα-[Nα-(tert-butyloxycabonyl)-L-glutaminyl]-N1-formyl-D-tryptophyl-L-phenylalanine benzyl ester
 
R Back to top
rilonacept Approved drug Immunopharmacology Ligand 6790 Arcalyst®, IL-1 Trap, interleukin-1 Trap
romiplostim Approved drug Immunopharmacology Ligand 6974 MG531, Nplate®
RSLV-132 Immunopharmacology Ligand 10412 RSLV132
 
S Back to top
SC-67655 Immunopharmacology Ligand 8889
SNG001 Immunopharmacology Ligand 11129
 
T Back to top
tadekinig alfa Immunopharmacology Ligand 10077
TC14012 Immunopharmacology Ligand 2902 TC 14012, TC-14012
teduglutide Approved drug Immunopharmacology Ligand 7049 ALX-0600, Gattex®, GLP2-2G, Revestive®
telitacicept Approved drug Immunopharmacology Ligand 11827 RC18, Tai'ai®
tethered chemerin 9 Immunopharmacology Ligand 9784
 
V Back to top
Vm24 Immunopharmacology Ligand 10050 α-KTx 23.1
voclosporin Approved drug Immunopharmacology Ligand 11388 1,11-anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl- N-methyl-L-valyl-[(2S,3R,4R,6E)-3-hydroxy-4-methyl- 2-(methylamino)nona-6,8-dienoyl][(2S)-2-aminobutanoyl]- N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine], E-ISA247, ISA(TX)247, ISA-247, ISA247, ISATX247, Lupkynis®, R 1524, R-1524, R1524
 
W Back to top
WKYMVm Immunopharmacology Ligand 1048 Trp-Lys-Tyr-Met-Val-[D]Met, WKYMVM
WRWWWW Immunopharmacology Ligand 1040 WRW4
 
Z Back to top
Z-FA-FMK Immunopharmacology Ligand 11257 MDL 201053, MDL-201053, MDL201053, Z-Phe-DL-Ala-fluoromethylketone, ZFA-fmk
zilucoplan Approved drug Immunopharmacology Ligand 10404 RA-101495, RA101495, Zilbrysq®