CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Medical Relevance
Many physiological conditions/malfunctions have been considered to be associated with various MCP-1 gene polymorphisms. For further information see GeneRIFs
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CCL2 C-C motif chemokine ligand 2 Human chemokine (C-C motif) ligand 2 chemokine (C-C motif) ligand 2, GDCF-2, HC11, MCAF, MCP1, MCP-1, MGC9434, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, monocyte chemotactic protein 1, homologous to mouse Sig-je, monocyte secretory protein JE, SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je), small inducible cytokine subfamily A (Cys-Cys), member 2, SMC-CF
Database Links Click here for help
Specialist databases
GPCRdb Ligand CCL2
Other databases
DrugBank Target P13500 (Hs)
Ensembl Gene ENSG00000108691 (Hs)
Entrez Gene 6347 (Hs)
GtoPdb PubChem SID 135651664
Human Protein Atlas ENSG00000108691 (Hs)
Immunopaedia Search CCL2
OMIM 158105 (Hs)
RefSeq Protein NP_002973 (Hs)
UniProtKB P13500 (Hs)
Wikipedia CCL2 (Hs)