ocrelizumab   Click here for help

GtoPdb Ligand ID: 7580

Synonyms: 2H7 | Ocrevus® | PRO70769 | RG1594
Approved drug Immunopharmacology Ligand
ocrelizumab is an approved drug (FDA (2017), EMA (2018))
Compound class: Antibody
Comment: Ocrelizumab is a humanized IgG1 anti-CD20 monoclonal antibody, approved for relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). This is the first therapeutic to gain approval for both of these forms of MS. Ocrelizumab is a modified version of rituximab, developed as a substitute in response to expiration of rituximab patent protection.
The submission documentation for the antibody's INN application contains the peptide sequences for the heavy and light chains of the antibody. BLAST searches of patented peptide sequences reveals identical matches with peptides claimed in patent WO2004056312, which resolve to clones 2H7.v16 and 2H7.v31 [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2017), EMA (2018))
International Nonproprietary Names Click here for help
INN number INN
8636 ocrelizumab
Synonyms Click here for help
2H7 | Ocrevus® | PRO70769 | RG1594
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 227
Other databases
GtoPdb PubChem SID 223365915
Search PubMed clinical trials ocrelizumab
Search PubMed titles ocrelizumab
Search PubMed titles/abstracts ocrelizumab
Wikipedia Ocrelizumab