dexamethasone   Click here for help

GtoPdb Ligand ID: 2768

Synonyms: Decadron® | desametasone | fluormethylprednisolone
Approved drug PDB Ligand Immunopharmacology Ligand
dexamethasone is an approved drug (FDA (1958), EMA (2010))
Compound class: Synthetic organic
Comment: Dexamethasone is a glucocorticoid receptor agonist with anti-inflammatory action.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dexamethasone

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 392.2
XLogP 1.14
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES OCC(=O)C1(O)C(C)CC2C1(C)CC(O)C1(C2CCC2=CC(=O)C=CC12C)F
Isomeric SMILES OCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F
InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI Key UREBDLICKHMUKA-CXSFZGCWSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1958), EMA (2010))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
International Nonproprietary Names Click here for help
INN number INN
816 dexamethasone
Synonyms Click here for help
Decadron® | desametasone | fluormethylprednisolone
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9660917
Reactome Reaction Reactome logo R-HSA-9678925
Other databases
BindingDB Ligand 18207
CAS Registry No. 50-02-2
ChEMBL Ligand CHEMBL384467
DrugBank Ligand DB01234
DrugCentral Ligand 824
GtoPdb PubChem SID 135651471
Immunopaedia Search dexamethasone
PubChem CID 5743
RCSB PDB Ligand DEX
Search Google for chemical match using the InChIKey UREBDLICKHMUKA-CXSFZGCWSA-N
Search Google for chemicals with the same backbone UREBDLICKHMUKA
Search PubMed clinical trials dexamethasone
Search PubMed titles dexamethasone
Search PubMed titles/abstracts dexamethasone
SynPHARM 6570 (in complex with Glucocorticoid receptor)
6583 (in complex with Mineralocorticoid receptor)
UniChem Compound Search for chemical match using the InChIKey UREBDLICKHMUKA-CXSFZGCWSA-N
UniChem Connectivity Search for chemical match using the InChIKey UREBDLICKHMUKA-CXSFZGCWSA-N
Wikipedia Dexamethasone