peginterferon alfa-2b   Click here for help

GtoPdb Ligand ID: 7462

Synonyms: PegIntron® | Sylatron®
Approved drug Immunopharmacology Ligand
peginterferon alfa-2b is an approved drug (EMA (2000), FDA (2001))
Compound class: Peptide or derivative
Comment: Peginterferon alfa-2b is a pegylated interferon protein. Conjugation with polyethylene glycol (PEG) is a strategy commonly used to protect peptide drugs from in vivo proteolytic breakdown to increase their biological half-life and duration of action.
Peginterferon alfa-2b is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Peptide Sequence Click here for help
CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETL
LDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQES
LRSKE
Cys-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Ser-Arg-Arg-Thr-Leu-Met-Leu-Leu-Ala-Gln-Met-Arg-Arg-Ile-Ser-Leu-Phe-Ser-Cys-Leu-Lys-Asp-Arg-His-Asp-Phe-Gly-Phe-Pro-Gln-Glu-Glu-Phe-Gly-Asn-Gln-Phe-Gln-Lys-Ala-Glu-Thr-Ile-Pro-Val-Leu-His-Glu-Met-Ile-Gln-Gln-Ile-Phe-Asn-Leu-Phe-Ser-Thr-Lys-Asp-Ser-Ser-Ala-Ala-Trp-Asp-Glu-Thr-Leu-Leu-Asp-Lys-Phe-Tyr-Thr-Glu-Leu-Tyr-Gln-Gln-Leu-Asn-Asp-Leu-Glu-Ala-Cys-Val-Ile-Gln-Gly-Val-Gly-Val-Thr-Glu-Thr-Pro-Leu-Met-Lys-Glu-Asp-Ser-Ile-Leu-Ala-Val-Arg-Lys-Tyr-Phe-Gln-Arg-Ile-Thr-Leu-Tyr-Leu-Lys-Glu-Lys-Lys-Tyr-Ser-Pro-Cys-Ala-Trp-Glu-Val-Val-Arg-Ala-Glu-Ile-Met-Arg-Ser-Phe-Ser-Leu-Ser-Thr-Asn-Leu-Gln-Glu-Ser-Leu-Arg-Ser-Lys-Glu
Chemical Modification
Covalently conjugated with monomethoxy polyethylene glycol (PEG) to reduce proteolytic cleavage and thereby increase the biological half-life of the interferon protein.